Phenelzine Linezolid

Isocarboxizid, phenelzine, selegiline, tranylcypromine, moclobemide, clorgiline, and linezolid... 

Clinically important, potentially hazardous interactions with amprenavir, clonidine, ephedra, epinephrine, eucalyptus, guanethidine, iobenguane, isocarboxazid, linezolid, MAO inhibitors, paroxetine, phenelzine, quinolones, sparfloxacin, St John s wort, tranylcypromine... 

Clinically important, potentially hazardous interactions with linezolid, memantine, moclobemide, phenelzine, rasagiline, sibutramine, tranylcypromine, valdecoxib... 

Clinically important, potentially hazardous interactions with alprazolam, amphetamines, astemizole, clarithromycin, clozapine, desipramine, dexibuprofen, dextroamphetamine, diethylpropion, droperidol, duloxetine, erythromycin, haloperidol, imipramine, isocarboxazid, linezolid, lithium, MAO inhibitors, mazindol, meperidine, methamphetamine, midazolam, moclobemide, nortriptyline, phendimetrazine, phenelzine, phentermine, phenylpropanolamine, phenytoin, pimozide, pseudoephedrine, selegiline, serotonin agonists, sibutramine, St John s wort, sumatriptan, sympathomimetics, tramadol, tranylcypromine, trazodone, tricyclic antidepressants, troleandomycin, tryptophan, zolmitriptan... 

Clinically important, potentially hazardous interactions with acyclovir, alcohol, amphetamines, barbiturates, CNS depressants, fluoxetine, furazolidone, general anesthetics, glycopyrrolate, glycopyrronium, isocarboxazid, linezolid, lithium, MAO inhibitors, moclobemide, phenelzine, phenobarbital, phenothiazines, rasagiline, ritonavir, selegiline, sibutramine, SSRIs, tranquilizers, tranylcypromine, tricyclic antidepressants, val acyclovir... 

Cases of death have been reported from MDMA interactions with the irreversible MAOl phenelzine and the reversible MAOl moclobemide. Linezolid, a new antibacterial with mild MAOl properties, may also interact dangerously with MDMA. The plasma concentration of MDMA increases 9-15% when the drug is taken with alcohol. More importantly, this combination leads to a longer-lasting feeling of euphoria and the false impression that one s performance of a task has improved when it has actually been impaired. 

The UK manufacturer contraindicates the concurrent use of linezolid with or within 2 weeks of taking any other drug that inhibits MAO-A or MAO-B. They specifically name the non-selective MAOIs isocarboxazid and phenelzine, the RIMA, moclobemide, and the MAO-B inhibitor, selegiline. Linezolid has reversible non-selective MAO-inhibitory activity, and this warning is based on the sometimes serious reactions that have occurred when non-selective MAOIs are given sequentially (see MAOIs + MAOIs or RIMAs , p.1137) or MAOIs are given with MAO-B inhibitors, see MAO-B inhibitors + MAOIs or RIMAs , p.692. 

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