Limulus anti-LPS factor

Hoess, A., Watson, S., Siber, G.R., Liddington, R. Crystal structure of an endotoxin-neutralizing protein from the horseshoe crab, Limulus anti-LPS factor, at 1.5 A resolution. EMBO J 12 (1993) 3351-3356. 

Morita, T., Ohtsubo, S., Nakamura, T., Tanaka, S., Iwanaga, S., Ohashi, K., Niwa, M. Isolation and biological activities of limulus anticoagulant (anti-LPS factor) which interacts with lipopolysaccharide (LPS). J Biochem (Tokyo) 97 (1985b) 1611-1620. 

The synthetic AMP synthesized here (PepLALp) was derived from the LPS-binding sequence of the Limulus polyphemus protein L/Vwi//i -anti-LPS factor (LALF) 10) (sequence see above), which was connected to a cycle along the two cysteins since it has been shown that cyclic LALF-peptides are better able to inhibit the LPS-induced cytokine secretion in human mononuclear cells than linear peptides II). Clearly, the peptide is multiply positively charged ( +7... 

Isolation and biological activities of Limulus anticoagulant (anti-LPS factor) which interacts with lipopolysaccharide (EPS) , J Biochem, 97, 1611-1620. 

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