Limitations of Aerosol Delivery

In general, the creation of aerosols is technically difficult, expensive, and time-consuming. Moreover, patients need to learn specific inhalation techniques for the correct use of inhaler devices [26], and many have difficulty in using MDIs properly. Aerosol preparations are associated with significant losses of drug. Furthermore, due to the inertial impaction of the administered aerosol particles, 

Kinget, and N. Verbeke. 2001. The lung as a route for systemic delivery of therapeutic proteins and peptides. Respir. Res. 2 198-209. 

2 Choi,W.S., G.G. Murthy, D.A. Edwards, R. Langer, and A.M. Klibanov. 2001. Inhalation delivery of proteins from ethanol suspensions. Proc. Natl. Acad. Sci. USA 98 11103-11107. 

3 Taylor, G., and L. Kellaway. 2001. Pulmonary Drug Delivery. In A. Hillery, 

Swarbrick (Eds), Drug Delivery and Targeting For Pharmacists and Pharmaceutical Scientists. Taylor, Francis, London, pp. 270-300. 

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