Limb splay

Figure 3 Illustration of the hind-limb splay procedure the hind paws of the mouse are dipped in ink, the animal is then dropped from a fixed height onto a piece of paper and the distance between some parameter of the hindlimbs is measured. (Reproduced from Cory-Slechta DA (1989) Behavioral measures of neurotoxicity. Neurotoxicology 0 . 271-296, with permission.)...

A narcotic-like stupor was observed during carbon disulfide exposure of rats at 600 ppm 10 hours a day for 14 days (Wilmarth et al. 1993). By the end of the study, mild ataxia and moderate hind-limb splay... 

M (Splayed hind limbs and flaccid paralysis of fore limbs in germ-free rats)... 

Rats injected with doses of 20-60 mg/kg of ibogaine displayed slower response times on sensory and sensory-motor tests and were also impaired in performing specific motor reflexes at doses of 40-60 mg/kg. Furthermore, these rats exhibited a marked reduction in locomotor activity as well as in emotionality at doses ranging from 10-40 mg/kg. At higher doses (> 40 mg/kg), rats appeared virtually inactive (78). In other studies, at doses above 25 mg/kg, ibogaine produced ataxia, splayed hind limbs, outstretched forelimbs, Straub tail, and hyperexcitability (79). 

Mouse P caribaeorum 0.72 (0.64-0.80) Abnormal gait, splaying of hind limbs, paralysis, dyspnea, deafii. No diarrhea No peritonitis or ascites. No other macroscopic changes [20]... 

Gait Described as hypotonic or hypertonic. Hypotonic gait is caused by muscle weakness ot paralysis and is manifested by splayed posture or a swaying/waddling walk. Hypertonic gait is caused by increased muscle tone or spasticity and is manifested by elevatimi of the hind limbs with limited movement and a shuffling walk or tiptoeing... 

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