Lignans deoxypodophyllotoxin

Podophyllotoxin (Fig. 4), a non-alkaloid toxin lignan, is a laxative, anti-tumor and antirheumatic agent. Cell cultures of Linum flavum were shown to be able to convert deoxypodophyllotoxin, a lignan isolated from Anthriscus sylvestris, into podophyllotoxin. ... 

Federolf, K., Alfermann, A.W. and Fuss, E. (2007) Aryltetralin-lignan formation in two different cell suspension cultures of Linum album Deoxypodophyllotoxin 6-hydroxylase, a key enzyme for the formation of 6-methoxypodophyllotoxin. Phytochemistry, 68,1397-A06. 

Molog, G.A., Empt, U., Kuhlmann, S., Van Uden, W., Eras, N., Alfermann, A.W. and Petersen, M. (2001) Deoxypodophyllotoxin 6-hydroxylase, a cytochrome P450 monooxygenase from cell cultures of Linum flavum involved in the biosynthesis of cytotoxic lignans. Planta, 214, 288-94. 

Isol. from seed oil of Hernandia ovigera. Lignan of deoxypodophyllotoxin type. 

Hokanson G C 1979 The lignans of Poly gala polygama (Polygalaceae). Deoxypodophyllotoxin and three new lignan lactones. J Nat Prod 42 378-384... 

Achiwa and co-workers developed a catalytic enantiose-lective hydrogenation of a-arylidenesuccinic acid half ester 140 en route to the stereoselective total syntheses of three naturally occurring lignans (+)-collinusin, (—)-deoxypodophyllotoxin, and (+)-neoisostegane (Scheme 29.9). ... 

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