Ligands ethyl nicotinate

Several other complexes with N-donor ligands have been prepared.1065 The complexes CoM(NCS)4(L)6 (M = Zn or Cd L = 2-, 3- or 4-cyanopyridine, nicotinamide, ethyl nicotinate or isonicotinic acid hydrazide) are best formulated as CoL6M(SCN)4. The complexes CoHg(SCN)4L2 (L = 2-, 3- or 4-aminopyridine, 3-cyanopyridine or ethyl nicotinate) possess only bridging SCN ligands, and have the polymeric structure (139). On the other hand, the complexes CoZn(NCS)4L2 (L = 2-, 3- and 4-aminopyridine) contain both bridging and terminal SCN groups, and are postulated to have the dimeric structure (140). 

Stoltz has reported the first oxidative indole aimulations that are catalytic in palladium, and two examples are illustrated below [46]. The ligand is ethyl nicotinate. 

Other parameters of the palladium(n)-catalysed benzofuran synthesis were explored. Ultimately, it was found that the ideal system employed a 2 1 ligand/palladium ratio (10mol% Pd(OAc)2 and 20mol% ethyl nicotinate) and a substoichiometric amount (20mol%) of NaOAc at 100 °C. With this system in hand, a variety of substituted benzo-furans were accessed (Figure 9.7). The reaction was limited to electron-rich aryl systems the palladation event required a sufficiently nucleophilic arene in order to occur. The aryl subunit, however, tolerated an array of alkyl and alkoxy substitution patterns within the... 

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