Ligand profiles

Bioprint Cerep s proprietary ligand profiling data including target-specific activity and ADME-related properties http //www.cerep.fr... 

Five membranes (thickness, 40 /am) were stacked and the concentration of ligand and cation in each membrane was measured before and immediately after the transport experiment as well as 5 days after restacking the membranes. Since a concentration gradient of valinomycin developed (Fig. 11, f = 3hr), which decayed almost completely after a relaxation period (Fig. 11, l = 5 days), the a-phenylethylammonium cation had obviously been transported by a carrier mechanism. During the transport process a cation profile built up (Fig. 12, t = 3 hr) that had the same trend as the ligand profile. This cation gradient disappeared after some time (Fig. 12, t = 5 days). 

Figure 10 Ligand profile plot for the grgi conformer of H2P- -Pr. The van der Waals contact surface is shown in the upper right figure and the atom numbering in the upper left figure. (Reprinted with permission from Ref 83. 1980 American Chemical Society)...

Figure 12 Oliver and Smith s presentation of a ligand profile showing the variation of van der Waals contacts with the rotation () about the M-P bond resulting in cone angle 0) variations. (Reprinted with permission from Ref. 86. 1978 American Chemical Society)...

Figure 4 Generation of a ligand profile for a PR3 ligand. As the ligand rotates about the M-P bond, (j), the half cone angle varies (shown on left). The plot of half cone angle versus (j) is the ligand profile (shown on right).

Hg(OAc)2(PCy3)2] (36). This conformational difference was rationalized by examining the ligand profiles of PCys in the two different environments. 

O., Miyazaki, N., Petrov, E.A., Batoev, V.B. and Tanabe, S. (2006) Constitutive androstane receptor (CAR) as a potential sensing biomarker of persistent organic pollutants (POPs) in aquatic mammal molecular characterization, expression level, and ligand profiling in Baikal seal (Pusa sibirica). Toxicological Sciences, 94, 57-70. 

J. Stevens, N. Razi, D.J. Stevens, J.J. Skehel, I. van Die, D.R. Burton, I.A. Wilson, R. Cummings, N. Bovin, C.-H. Wong, J.C. Paulson, Printed covalent glycan array for ligand profiling of diverse glycan binding proteins, Proc. Natl. Acad. Sci. U.S.A. 2004, 101, 17033-17038. 

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