Ligand binding alternative approach

Possible applications of MIP membranes are in the field of sensor systems and separation technology. With respect to MIP membrane-based sensors, selective ligand binding to the membrane or selective permeation through the membrane can be used for the generation of a specific signal. Practical chiral separation by MIP membranes still faces reproducibility problems in the preparation methods, as well as mass transfer limitations inside the membrane. To overcome mass transfer limitations, MIP nanoparticles embedded in liquid membranes could be an alternative approach to develop chiral membrane separation by molecular imprinting [44]. 

This book attempts to describe alternative approaches to ligand reactivity involving normal co-ordination complexes as opposed to organometallic compounds. In part, a justification for this view comes from a study of natural systems. With very few exceptions, organometallic compounds are not involved in biological systems it is equally true that numerous enzymes bind or require metal ions that are essential for their activity. If enzymes can utilise metal ions to perform complex and demanding organic chemical reactions in aqueous, aerobic conditions at ambient temperature and pressure, it would seem to be worthwhile to ask the question whether this is a better approach to catalysis. 

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