SEARCH Articles Figures Tables Approaches to Structure-Based Ligand Design Discrete ligand approach Experimental Approaches to Determine the Thermodynamics of Protein-Ligand Interactions Fragmentation approaches, ligand General Discussion of Ligand Design Approaches Homo and Heterodimer Ligands the Twin Drug Approach Ligand binding alternative approach Ligand design fragment-based approaches Ligand group orbital approach Ligand group orbital approach bonding Ligand group orbital approach linear molecules Ligand group orbital approach triatomic molecules Ligand structures building block approach Ligand-based Combinatorial Design The RADDAR Approach Ligand-based approach Ligand-based approach predicting functional sites Ligand-receptor interactions, computational approach Mixed ligand approach Overview of Approximate Approaches for Multiple-Ligand Screening Twin drug approach heterodimer ligands