Ligand agonism

Completely different Physiological phenotype ligand relevant agon ism or... 

This term indicates a receptor ligand having different intrinsic activities at different transduction pathways coupled to a single receptor. To quote Urban et al. (2006 JPET, 104463 PiP) and Kenakin (2007 Trends Pharmacol Sci 28 359-361) the term biased agonism can be considered as a synonym of collateral efficacy, ... 

Dysfunction of the GABAa receptor complex such that the effects of all benzodiazepine receptor ligands are shifted in the direction of inverse agonism. In this case, fiumazenil (which normally has zero efficacy) should induce anxiety in anxious patients but have no effects in healthy subjects because they have normal receptors. 

Agonism and Inverse Agonism Are the Basic Properties of Ligands Alone... 

Kenakin T., Inverse, protean, and ligand-selective agonism matters of receptor conformation, FASEB J., 15(3), 598-611, 2001. 

Ebersole, B. J., Visiers, I., Weinstein, H., and Sealfon, S. (2003) Molecular basis of partial agonism orientation of indolamine ligands in the binding pocket of the human serotonin 5-HT2A receptor determines relative efficacy. Mol. Pharmacol. 63, 36—43. 

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