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Ligand inverse agonism

Dysfunction of the GABAa receptor complex such that the effects of all benzodiazepine receptor ligands are shifted in the direction of inverse agonism. In this case, fiumazenil (which normally has zero efficacy) should induce anxiety in anxious patients but have no effects in healthy subjects because they have normal receptors. [Pg.410]

Agonism and Inverse Agonism Are the Basic Properties of Ligands Alone... [Pg.82]

Kenakin T., Inverse, protean, and ligand-selective agonism matters of receptor conformation, FASEB J., 15(3), 598-611, 2001. [Pg.109]

See other pages where Ligand inverse agonism is mentioned: [Pg.49]    [Pg.49]    [Pg.49]    [Pg.50]    [Pg.184]    [Pg.279]    [Pg.293]    [Pg.97]    [Pg.97]    [Pg.98]    [Pg.260]    [Pg.66]    [Pg.104]    [Pg.50]    [Pg.81]    [Pg.146]    [Pg.111]    [Pg.112]    [Pg.223]    [Pg.225]    [Pg.215]    [Pg.217]    [Pg.218]    [Pg.268]    [Pg.51]    [Pg.51]    [Pg.51]    [Pg.52]    [Pg.77]    [Pg.88]    [Pg.110]    [Pg.23]    [Pg.108]    [Pg.75]    [Pg.75]    [Pg.942]    [Pg.45]    [Pg.465]    [Pg.912]   
See also in sourсe #XX -- [ Pg.97 , Pg.98 ]



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Agonism

Inverse agonism

Ligand agonism

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