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Ligand-active site interactions

The molecular surface of receptor site regions cannot be derived from the structure infoi mation of the molecule, bth represents the form ofthe active site of a protein surrounded by a ligand. This surface representation is employed in drug design in order to illustrate the volume of the pocket region or the molecular interaction layers [186. ... [Pg.128]

In addition to halopeiidol, the putative neuroleptics, limcazole (311), lemoxipiide (312), and gevotioline (313) bind to (7-ieceptois as does the dopamine uptake blocker, GBR 12909 (314) and two ligands active at the NMDA receptor, ifenprodil (315) and CNS 1102 (316). NPC 16377, (317) is a selective (7-teceptor ligand. MAO inhibitors and antidepressants also bind to (7-teceptors. Some evidence indicates that (7-teceptors in the brain are in fact a form of cytochrome which may account for the diversity of ligands interacting with (7-sites. [Pg.573]

See other pages where Ligand-active site interactions is mentioned: [Pg.136]    [Pg.138]    [Pg.136]    [Pg.138]    [Pg.631]    [Pg.486]    [Pg.2248]    [Pg.44]    [Pg.63]    [Pg.2028]    [Pg.556]    [Pg.598]    [Pg.502]    [Pg.6]    [Pg.2247]    [Pg.187]    [Pg.505]    [Pg.73]    [Pg.38]    [Pg.271]    [Pg.346]    [Pg.10]    [Pg.10]    [Pg.240]    [Pg.182]    [Pg.361]    [Pg.105]    [Pg.391]    [Pg.463]    [Pg.387]    [Pg.667]    [Pg.779]    [Pg.1258]    [Pg.1286]    [Pg.33]    [Pg.116]    [Pg.300]    [Pg.395]    [Pg.406]    [Pg.307]    [Pg.358]    [Pg.389]    [Pg.20]    [Pg.327]    [Pg.8]    [Pg.31]    [Pg.36]    [Pg.71]    [Pg.293]   
See also in sourсe #XX -- [ Pg.136 ]



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Active Ligands

Interaction sites

Interactive sites

Ligand activated

Ligand interactions

Ligand sites

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