Lifson, Shneior

Levine Raphael David 144, 766, 845 Levitt Michael 285 Levy Bernard 397, 398, 400, 536 Levy Mel 569,581,582,611 Lewis Gilbert Newton 6, 7, 327 Lifson Shneior 277, 289 Linderberg Jan 672,679... 

M. Levitt and Shneior Lifson. Refinement of protein conformation using a macromolecular energy minimization procedure. J. Mol. Biol., 46 269-279, 1969. 

Dyson s model has been the subject of careful criticism as well as well-meaning agreement. Shneior Lifson (1997) found fault in particular with Dyson s assumption that metabolism (and other properties) could have developed without natural selection. In his third assumption, Dyson postulates that There is no Darwinian selection. Evolution of a molecule population occurs via genetic drift (Dyson, 1999). Lifson (1997) points out that, while Dyson stresses the role of primitive metabolism, its adaptability, error tolerance etc., he himself considers that such properties can only evolve via natural selection. 

Acknowledgment I thank Prof. Shneior Lifson and Prof. Jack Dunitz for promoting and stimulating my interest in force-field calculations. Financial support of the Deutsche Forschungsgemein-schaft is also gratefully acknowledged. 

There is no more classical work on dynamics than the monumental Philosophiae Naturalis Principia Mathematica , Cambridge University Press, A.D. 1687 of Isaac Newton. The idea of the force field was first presented by Mordechai Bixon and Shneior Lifson in Tetrahedron 23 (1967) 769 and entitled Potential Functions and Conformations in Cycloalkanes . 

Warshel restrict, if my interpretation is correct, the deviation in a difference between two molecules to a deviation in one of them. Finally, the following point of view should be considered There should be something left out from optimisation, to see whether a final potential energy function is not only internally" consistent, but also consistent with external data. The argument came from Martin Karplus during our many discussions in Rehovot in the last months of 1969. I should add that it did not then coincide with the views of Shneior Lifson, but has been used in recent work. ... 

Three men meant a lot to me in the formative years of my scientific career, and still do Niels Hofman-Bang, Flemming Woldbye and Shneior Lifson. Professor Hofman-Bang was Director of Chemistry Department A for many years, and responsible for employing me in... 

Professor Shneior Lifson was founder and for many years director of Chemical Physics Department at the Weizmann Institute of Science in Israel. He introduced me unreservedly to the methods for which he, with Bixon, Warshel and Levitt, laid the foundations, and during my stays in Rehovot I always had the benefit of his help and advice. Even more than that our family always felt a warm welcome with Shneior Lifson, his wife Hanna, and the whole department. 

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