Life-enhancing drugs

Werhane, Patricia H. and M. Gorman. 2005. Intellectual Property Rights, Access to Life-Enhancing Drugs, and Corporate Moral Responsibilities. Business Ethics Quarterly 15 595-613. 

A >. (X Eh X o (X e Eh o PO. 50% bioavailability, >90% plasma protein bound, half-life = 2-3 hrs, eliminated as unchanged drug and as metabolites. Phenobarbital shortens its half-life. Enhances actions of other antihypertensives, may produce severe hypotension. Because of severe ortho -static hypotension, patients should be lying down and observed for at least two hours after initial doses. 

Cardiovascular Life-threatening junctional bradycardia occurred in a patient with a high serum phenytoin concentration (91 mg/1, 23 pmol/1). The authors suggested that in this case severe cardiotoxicity had been caused by the high concentration of phenytoin and the presence of predisposing factors that enhanced drug toxicity [242 ]. 

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