Chlordiazepoxide Librium

Trade names of some benzodiazepines are Ativan (lorazepam), Dalmane (flurazepam), Halcion (triazolam), Klonopin (clonazepam). Librium (chlordiazepoxide), Restoril (temazepam), Serax (oxazepam). Valium (diazepam). Versed (midazolam), and Xanax (alprazolam). Some street names include benzos, downers, and goofballs. The date rape drug Rohypnol (flunitrazepam) has its own group of names, including forget-me pill, Mexican valium, mind erasers, R2, roches, roofies, rope, and rophies (Figure 7.2). Except for Rohypnol , which cannot be sold in the United States, the benzodiazepines are listed as Schedule IV drugs. 

Librium chlordiazepoxide. lidamidine [inn] (lidamldine hydrochloride [usan]) is an iminomethylurea, an (az) a-ADRENOCEPTOR agonist with ANTIDIARRHOEAL and antiperistaltic activity. 

Benzodiazepines. After the first phase of the launch of heterocyclic sedative-hypnotics, as exemplified by glutethimide and methyprylone, most significant milestones were reached by Roche. In 1960, Roche launched Librium (chlordiazepoxide)and in 1963, Valium (diazepam). These two compounds were the first two 1,4-benzodiazepine class compounds launched in the world. Subsequently a number of companies launched several other 1,4-benzodiazepines for a number of indications (sedative-hypnotic, anxiolytic, anticonvulsant, and muscle relaxant). 

The second major class of depressants is the benzodiazepines. The familiar tranquilizers Librium (chlordiazepoxide) and Valium (diazepam) are members of this group. Both the barbiturates and the benzodiazepines... 

In 1960, the sedative, muscle-relaxing and anticonvulsant properties of 7-chloro-tV-methyl-5-phenyl-3//-l, 4-benzodiazcpin-2-amine 4-oxide ( chlordiazepoxide ) led to its introduction into clinical use as the active ingredient of the tranquilizer Librium . 

Benzodiazepines such as chlordiazepoxide (Librium) and diazepam (Valium) were discovered in the early 1960s and found to have clinically important anxiolytic. 

Chlordiazepoxide Librium Oral Long 15-100 Anxiety disorders, alcohol withdrawal... 

Benzodiazepines. Like the barbiturates, benzodiazepines bind to the GABA receptor and are therefore cross-tolerant with alcohol. As a result, they also make suitable replacement medications for alcohol and are widely used for alcohol detoxification. Theoretically, any benzodiazepine can be used to treat alcohol withdrawal. However, short-acting benzodiazepines such as alprazolam (Xanax) are often avoided because breakthrough withdrawal may occur between doses. Intermediate to long-acting benzodiazepines including chlordiazepoxide (Librium), diazepam (Valium), oxazepam (Serax), lorazepam (Ativan), and clonazepam (Klonopin) are more commonly utilized. 

A series of tranquilizers, drugs that relieve anxiety and nervous tension without impairing consciousness, have a benzene ring fused to a seven-membered ring containing two nitrogens. As a group they are called benzodiazepines. The two most successful are diazepam (Valium ) and chlordiazepoxide (Librium ) introduced in 1964 and 1960, respectively. Flurazepam (Dalmane ), first used in 1970, is a hypnotic. 

Chlordiazepoxide (Librium, Mitran, libritabs) [C-IV] [Anxiolytic, Sedative/Hypnotic/Benzodiazepine] Uses Anx-... 

Withdrawal from long-term high-dose use of alcohol or sedative-hypnotic drugs can be life threatening if physical dependence is present. Benzodiazepines, such as chlordiazepoxide Librium) and diazepam Valium), are sometimes used to lessen the intensity of the withdrawal symptoms when alcohol or sedative-hypnotic drug use is discontinued. Benzodiazepines are also employed to help relieve the anxiety and other behavioral symptoms that may occur during rehabilitation. 

During the early twentieth century the barbiturates were used in children and adolescents for their sedative and hypnotic effects however, their safety profile and propensity to cause physical dependence led scientists in search of safer anxiolytics. The development of animal models of behavioral disorders facilitated the formulation of drugs with more specific central nervous system (CNS) effects. In 1959, chlordiazepoxide (Librium) was the first benzodiazepine (BZ) to receive a patent. It entered the market in 1960, followed by diazepam (Valium) in 1963. Today, over 35 BZs have been formulated and over 10 are available in the United States (Ballenger, 1995 Hobbs et ah, 1996). 

Chlordiazepoxide (Librium) Desmethyl- chlordiazepoxide Demoxepam Nordiazepam Oxazepam Intermediate Long Phase I... 

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