Libraries drug discovery

R and M M Hann 2000. The In Silico World of Virtual Libraries. Drug Discovery Today 5 326-336. R and I D Kuntz 1990. Conformational Analysis of Flexible Ligands in Macromolecular eptor Sites. Journal of Computational Chemistry 13 730-748. 

Leach, A. R. and Hann, M. M. (2000) The in silico world of virtual libraries. Drug Discovery Today 5, 326-336. 

Orry, A. J. W., Abagyan, R. A., and Cavasotto, C. N. (2006). Structure-based Development of target-specific compound libraries. Drug Discovery Today 11, 261-6. 

Richard A. Houghten, Darcy B. Wilson and Clemencia Pinilla, Drug discovery and vaccine development using mixture-based synthetic combinatorial libraries. Drug Discovery Today, 5 (2000), 276—285. 

Leach A R and M M Harm 2000. The In Silico World of Virtual Libraries. Drug Discovery Today 5 326-336. 

W. C. Ripka, G. Barker, J. Krakover, High-throughput purification of compound libraries. Drug Discovery Today 2001, 6, AHX-All. 

E J, J M Blaney, M A Siani, D C Spellmeyer, A K Wong and W H Moos 1995. Measuring fersity Experimental Design of Combinatorial Libraries for Drug Discovery. Journal of dicinal Chemistry 38 1431-1436. 

MA Gallop, RW Baii et, WJ Dower, SPA Fodor, EM Gordon. Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries. J Med Chem 37 1233-1251, 1994. 

Experimental design of combinatorial libraries for drug discovery. J Med Chem 38(9) 1431-1436, 1995. 

A Polmski, RD Eemstem, S Shi, A Kuki. LiBrain Software for automated design of exploratory and targeted combinatorial libraries. In IM Chaiken, KD Janda, eds. Molecular Diversity and Combinatorial Chemistry Libraries and Drug Discovery. ACS Conf Proc Ser. Washington, DC Am Chem Soc, 1996, pp 219-232. 

Combinatorial chemistry has played an increasing role in drug discovery. Wacker et al. extended the Madelung indole process successfully to solid phase library synthesis for the preparation of 2,3-disubstituted indoles. A number of examples follow in the table. 

To speed the process of drug discovery, combinatorial chemistry> has been developed to prepare what are called combinatorial libraries, in which anywhere from a few dozen to several hundred thousand substances are prepared simultaneously. Among the early successes of combinatorial chemistry is the development of a benzodiazepine library, a class of aromatic compounds much used as antianxiety agents. 

Combinatorial chemistry, a new chapter of organic synthesis, is now developing rapidly. This new approach to synthesizing large designed or random chemical libraries through application of solid phase synthetic methods, promises to revolutionize the process of drug discovery in the pharmaceutical industry.24... 

Drug Discovery via Smaii-Moiecuie Peptoid Libraries... 

Because of their ease of synthesis and their structural similarity to peptides, many laboratories have used peptoids as the basis for combinatorial drug discovery. Peptoids were among the first non-natural compounds used to establish the basic principles and practical methods of combinatorial discovery [17]. Typically, diverse libraries of relatively short peptoids (< 10 residues) are synthesized by the mix-and-split method and then screened for biological activity. Individual active compounds can then be identified by iterative re-synthesis, sequencing of compounds on individual beads, or indirect deduction by the preparation of positional scanning libraries. 

Drug Discovery via Small-Molecule Peptoid Libraries I 7... 

Davies K. Using pharmacophore diversity to select molecules to test from commercial catalogues. In Chaiken IM and Janda KD, editors. Molecular diversity and combinatorial chemistry. Libraries and drug discovery. Washington DC American Chemical Society, 1996 309-16. 

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