Lewisite developmental effects

Human data regarding reproductive/developmental effects due to lewisite exposure are inconclusive because of confounding factors such as concurrent exposure to other agents such as sulfur mustards and incomplete exposure data. Yamakido et al. (1985) studied workers from the Okuno-jima (Japan) factory where mustard and lewisite were manufactured in the World War II era, and noted no evidence of agent-induced mutations. 

Human data concerning the toxicity of lewisite via the oral route of exposure are not available. However, there are limited toxicity data on lewisite ingestion from animal studies. In animals, ingestion of lewisite can produce acute inflammation of the mucous membrane of the stomach or intestine, which is characterized by hemorrhage, necrosis of the epithelium, and submucous edema. Developmental effects have been reported in pregnant rats and rabbits... 

We do not know whether Lew isite or Mustard-Lewisite can cause developmental effects in humans. 

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