Levonorgestrel implants

Levonorgestrel implants consist of 6 Silastic capsules each capsule is 2.4 mm in diameter and 34 mm in length and contains 36 mg levonorgestrel. Total administered (implanted) dose is 216 mg. Perform implantation of all 6 capsules during the first 7 days of menses onset. Insertion is subdermal in the mid-portion of the upper arm (see literature included with the product). 

Annual and 5-Year Cumulative Pregnancy Rates Per 100 Levonorgestrel Implant Users by Weight ... 

Studies indicate a significant trend toward higher rates of Ml and strokes with increasing doses of progestin in combination oral contraceptives. There have been postmarketing reports of Ml coincident with levonorgestrel implant system use. 

Physical examination and follow-up Take a complete medical history and physical examination prior to the implantation or re-implantation of levonorgestrel implants and at least annually during its use. Carefully monitor women with a strong family history of breast cancer or who have breast nodules. 

Drug/Lab test interactions Certain endocrine tests may be affected by levonorgestrel implants Sex hormone binding globulin concentrations are decreased thyroxine concentrations may be slightly decreased and triiodothyronine uptake increased. 

Meirik O, Farley TM, Sivin I. Safety and efficacy of levonorgestrel implant, intrauterine device, and sterilization. Obstet Gynecol 2001 97(4) 539-47. 

Extensive clinical trials and premarketing studies were conducted before the Norplant (levonorgestrel) implant was registered and approved, in order to elucidate its... 

Extensive clinical trials and premarketing studies were conducted before the Norplant (levonorgestrel) implant was registered and approved, in order to elucidate its mode of action, effectiveness, and adverse effects. However, none of these trials included either teenagers under 18 years of age or nulligravid women. 

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