Moclobemide Levodopa

Bromocriptine is a dopamine agonist acting by direct stimulation of the dopamine receptors. In Parkinson s disease, it is reserved for use in patients who are intolerant to levodopa or in whom levodopa alone is not sufficient. Orphenadrine is an antimuscarinic indicated in Parkinson s disease. Antimuscarinics tend to be more effective than levodopa in targeting tremor rather than rigidity and bradykinesia. Moclobemide is an antidepressant referred to as a reversible monoamine oxidase inhibitor (RIAAA) type A. 

Tyramine-rich foods, sympathomimetics, dextromethorphan, anorectics, and other antidepressants should be avoided when treating with moclobemide. It also interacts with opioid analgesics, serotonin agonists, NSAIDs, levodopa, and cimetidine.140,141... 

Risk of hypertensive crisis may be increased if moclobemide is used concurrently with levodopa or other dopaminergic agents... 

Clinically important, potentially hazardous interactions with carbidopa, citalopram, doxepin, ephedra, ephedrine, escitalopram, fluoxetine, fluvoxamine, levodopa, meperidine, moclobemide, nefazodone, oral contraceptives, paroxetine, sertraline, venlafaxine... 

A study in 12 healthy subjects given a single dose of levodopa/benserazide with moclobemide 200 mg twice daily found that nausea, vomiting and dizziness were increased, but no significant hypertensive reaction was seen. ... 

No important acute adverse interaction appears to occur between levodopa/benserazide and moclobemide, but some adverse effects can apparently occur. 

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See also in sourсe #XX -- [ ]

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