Levallorphan tartrate

Piminodine (Alvodine ), ethyl-4-phenyl-l-(3-phenylaminopropyl)piperidine-4-carboxylate ethanesulfonate, is reputed to be equal to morphine in analgesic potency, but relatively free of the latter s narcotizing action. It is administered in doses of 25 to 50 mg orally every 4 to 6 h, or in doses of 10 to 20 mg subcutaneously or intramuscularly every 4 h as needed. Piminodine is habit forming, requires a narcotic prescription, and should be used with the same precautions as other members of this group. Levallorphan tartrate, nalorphine, naloxone, or naltrexone are antidotes to it. 

Dose. 0.5 to 1 mg of levallorphan tartrate intravenously, repeated if necessary. 

Levallorphan Tartrate 450.1 Octaphonium Chloride 473.6 Alverine Citrate... 

Potentiometric H2O Rudy BC and Senkowski BZ, Levallorphan tartrate, APDS, 2,339-361... 

Levallorphan tartrate occurs as a white or practically white, odorless, crystalline powder. 

The IR spectrum of levallorphan tartrate is greatly complicated by the presence of the tartaric acid. To obtain the IR spectrum characteristic of the active species, the free levallorphan base was extracted from a basic solution, dried, and measured as a KBr dispersion (1.7 mg levallorphan/300 mg KBr) on a Perkin Elmer 621 Spectrophotometer. This spectrum is shown in Figure 1 and the assignments for the characteristic bands are given in Table I (1). 

The UV spectra of levallorphan tartrate in water (A) and in IN NaOH (B) are shown in Figure 3 (3). The maxima and minima as well as the molar extinction coefficients at the are listed in Table III. The values... 

The excitation and emission spectra for levallorphan tartrate (1 mg/ml of methanol) is shown in Figure 4 (6). Two maxima appear in the excitation spectrum at 306 nm. When O.IN HCl is used as the solvent the maxima occur at the same wavelengths but a 5 fold increase in sensitivity is obtained. 

The specific rotation of levallorphan tartrate in water at 25°C is plotted versus wavelength in Figure 6 (3, 8). The specific rotation observed at 589 nm was -39.0°. 

The melting range reported in the USP XVIII for levallorphan tartrate is 174° to 177° using the class la procedure (9). 

The DSC curve shown in Figure 7 for levallorphan tartrate was obtained using a Perkin Elmer DSC-IB Calorimeter. With a temperature program of 10°C/min, a melting... 

Plot of Specific Rotation vs. Wavelength of Levallorphan Tartrate... 

The TGA scan run on levallorphan tartrate showed no weight loss from 30° to 217°C. One continuous weight loss occurred from 217° to 470°C which accounted for essentially all of the sample (10). 

---