Leuprolide, structure

Leuprolide, structure of, 1056 I.evorotatory, 295 Lewis, Gilbert Newton. 8 Lewis acid, 57-58 examples of, 58 reactions of, 57-58 Lewis base, 57, 59-60 examples of, 59 reactions of, 59-60 Lewis structure, 9 resonance and, 43 Lexan, structure and uses of, 819,... 

Fig. 6.39. The structure of LHRH (6.89), leuprolide (6.90), deslorelin (6.91), and nafarelin (6.92). Also shown is the metabolism of nafarelin in humans [215].

It should be mentioned that crystal structure data are often obtained from co-solvent systems (Desai and Klibanov, 1995). For example, crystals of ubiqui-tin, papain and a heptapeptide were grown from 30% polyethylene glycol (PEG) 4000, 62% MeOH and a DMSO/isopropanol mixture, respectively (Kamphius et al., 1984 Karle et al., 1993 Love et al., 1997). The orthogonal and tetratogonal crystal forms of cyclosporine were prepared from 25% PEG 300 and acetone, respectively (Petcher et al., 1976 Kessler et al., 1985 Loosli et al., 1985 Verheyden et al., 1994a). Furthermore, cyclosporine and leuprolide form thermotropic liquid crystals when dried from EtOH and lyotropic liquid crystals when solubilized in PG, respectively (Tan et al., 1998 Lechuga-Ballesteros et al., 2003 Stevenson et al., 2003). 

Figure 6.3-2. Schematic presentation of primary structure of luteinizing hormone-releasing hormone (LH-RH) and leuprolide acetate.

Several GnRH agonists are available, including leuprolide acetate (Lupron) and goserelin acetate (Zoladex), which are injectable agents, and nafarelin acetate (Synarel), which is administered via nasal spray. (Discussion about structure-activity relationships can be found in Chapter 7.)... 

C) Write the structure of leuprolide using both one- and three-letter abbreviations. 

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