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Leukemia, xenograft models

No rodent bioassay Tumor promotion potential was evaluated by first identifying human tumor cell lines that bind natalizumab in vitro Tumor promotion potential was then evaluated by assessing tumor growth in athymic nude mice after tumor transplantation (sc) followed by treatment with natializumab. Natalizumab did not show any tumor promoting potential on two oc4 expression tumors (leukemia, melanoma) in a nude mouse xenograft model Not genotoxic (Ames, in vitro chromosomal aberrations in human PBLs)... [Pg.1051]


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See also in sourсe #XX -- [ Pg.8 ]




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