Leucine ethyl ester

Poly-N-[l-carbetoxy-3-methyl-butyl]-acrylamide (XXVIII) has been prepared from poly-acrylyl-chloride (XXIX) and leucine ethyl ester (XXX) ([a]f)° + 13.1) according to Scheme 5. 

The polymer in solution has rotatory power, [a] — 36.3 (c = 2.5 in acetone), strongly depending on the type of solvent used, and of opposite sign with respect to the leucine ethyl ester (XXX). A similar change in the sign of the rotatory power has been observed by acetylating leucine (132). 

Product prepared from FPC by treatment with papain for 30 min in the presence of L-leucine ethyl ester (Leu-OC2). Similar notations are used for other products resulting from the papain treatment of succinylated proteins in the presence of L-leucine 77-alkyl esters. 

LME = leucine methyl ester, LEE = leucine ethyl ester,... 

N Protectlve group in peptide synthesis. The reagent provides a new and improved method for the preparation of N-t-butyloxycarbonyl derivatives of amino acids or peptides, since it reacts with the NHj group with elimination of HCN to form the derivative, as illustrated for L-leucine ethyl ester. The reactants are mixed at (f and agitated at room temperature for 1 hr. The solvent is evaporated and the product isolated from the dried neutral fraction. 

Li G, et al. (2008) Protease-Catalyzed Co-Oligomerizations of L-Leucine Ethyl Ester with L-Glutamic Acid Diethyl Ester. Macromolecules. 41 p. 7003-7012. 

There are several interesting transformations of leucine that ultimately lead to statine. One method converted L-leucine ethyl ester to amide 6.725.93 a Dieckmann cyclization followed by decarboxylation gave keto-lactam 6.126 from... 

Zhang C, Liu F, Li Y, Shen X, Xu X, Sakai R, Satoh T, Kakuchi T, Okamoto Y (2013) Influence of stereoregularity and linkage groups on chiral recognition of poly-(phenylacetylene) derivatives bearing L-leucine ethyl ester pendants as chiral stationary phases for HPLC. J Polym Sci A Polym Chem 51 2271-2278... 

Figure 7.28 Synthesis of unimolecular reversed micelle (25) consisting of hydrophilic hyperbranched D-glucan core and hydrophobic L-leucine ethyl ester shell.

Na-benzoyl-tyrosine-p-nitroanilide 4-(HO)C6H4CH2CH(NHCOC6H5)CONHC6H4N02. L-leucine ethyl ester (CH3)2CHCH2CH(NH2)C02C2H5. 

The compounds (Figure 50.13) Af-(3,5-dinitrobenzoyl)-l-phenylethylamine 39, A -(3,5-dinitrobenzoyl)-L-leucine ethyl ester(40), ° A -(3,5-dinitrobenzoyl)-4-amino-3-methyl-l,2,3,4-tetrahydrophenanthrene 41, and 1-(1-... 

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