Arthralgia letrozole

Letrozole is another selective aromatase that inhibits the conversion of androgens to estrogen. Maximum plasma concentrations occur 1 hour after oral dosing concomitant food has not been shown to have an effect on the extent of absorption of letrazole. The terminal half-life is approximately 2 days. Letrozole is used in the treatment of postmenopausal women with hormone-receptor-positive or unknown advanced breast cancer. Side effects include bone pain, hot flushes, back pain, nausea, arthralgia, osteoporosis/bone fractures, and dyspnea. 

Nonsteroidal Steroidal Anastrozole Letrozole Exemestane 1 mg orally daily 2.5 mg orally daily 25 mg orally daily Hot flashes, arthralgias, myalgias, headaches, diarrhea, mild nausea, osteoporosis (boneloss)... 

Options for adjuvant hormonal therapy in postmenopausal women include aromatase inhibitors (e.g. anastrozole, letrozole, or exemestane) either in place of or after tamoxifen. Adverse effects with aromatase inhibitors include hot flashes, myalgia/arthralgia, vaginal dryness/atrophy, mild headaches, and diarrhea. 

Letrozole 2.5 mg orally daily Mild nausea, headache Fatigue, hot flushes, arthralgias... 

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