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Lesion expansion

Several studies have evaluated the effect of tPA treatment administered at variable timepoints after clot embolization (Brinker et al. 1999 Busch et al. 1998 Franke et al. 2000 Jiang et al. 2000). Early lesion expansion as visible on DWI could only be reversed or slowed down if thrombolysis-induced reperfusion was initiated early after the onset of ischemia (Fig. 4.14). For example, if tPA was given at 1.5 h post occlusion the DWI lesion did not further enlarge whereas thrombolysis at later timepoints did not attenuate lesion growth (Brinker et al. 1999). Correlation analysis with other MR parameters revealed that areas with increased lactate or T2 values did not improve when tPA was started > 3 h after the insult (Franke et al. 2000). By using histological means, other investigators however... [Pg.59]

Fig. 3.3. There is no significant difference in size between the acute perfusion (TTP) and diffusion (DWT) lesion scans, nonmismatch. On follow-up T2-weighted imaging there has been no expansion of the infarct core... Fig. 3.3. There is no significant difference in size between the acute perfusion (TTP) and diffusion (DWT) lesion scans, nonmismatch. On follow-up T2-weighted imaging there has been no expansion of the infarct core...
Babbe H, Roers A, Waisman A, Lassmann H, Goebels N, Hohlfeld R, Fiiese M, Sclri oder R, Deckat M, Sclrmidt S, Ravid R, Rajewsky K (2000) Clonal expansions of CD8(+) T cells dominate die T cell inlilti ate in acdve muldple sclerosis lesions as sliown by micromanipuladon and single cell polymerase chain reacdon. J Exp Med 192 393 04. [Pg.252]

Anorexigen-associated severe pulmonary hypertension is clinically and histopathologically indistinguishable from idiopathic or primary pulmonary hypertension. Analysis of clonaUty in microdissected endothelial cells of plexi-form lesions in two patients with anorexigen-associated pulmonary hypertension showed a monoclonal expansion of pulmonary endothelial cells. Accelerated growth of pulmonary endothelial cells in response to anorexigens in patients with predisposition to primary pulmonary hypertension has been speculated (75). [Pg.1339]

The expansion or new development of tuberculous lesions during ultimately successful therapy has been termed a paradoxical response. It is most often reported in relation to intracranial tuberculomata, but is probably most common in tuberculous lymphadenopathy. It is also described in tuberculous pleurisy and in parenchjmal lung disease. In most cases, the problem eventually settles, but sometimes glucocorticoid therapy is used empirically. [Pg.1926]

The remaining mutations are mostly larger lesions and comprise only 7% of human mutations. These include whole gene duplications and deletions, SSR expansions (e.g., trinucleotide repeat expansions), gene rearrangements (e.g., B-and T-cell gene rearrangements), and complex polymorphic loci related to health and disease (e.g., HLA). [Pg.1408]

The majority of small lymphocytes in early MS lesions and in the hypercellular edge of plaques extending into normal white matter are CD4-positive T lymphocytes.108110 T lymphocytes of the CD8 phenotype are present in early lesions but this population predominates in later lesions.111 Examination of the distribution of T-lymphocyte subsets in MS plaques of different activity has led to the proposal that CD4-positive cells are responsible for the development and expansion of lesions, whilst the CD8-positive subset controls their local activity.110112... [Pg.68]


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Lesion

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