Least identifiability

In such cases, the chemist who wishes to design a safer analog of the original chemical should make an attempt to learn what the mechanism of toxicity is, or at least identify plausible possibilities as to what the toxicity mechanism(s) may be. Such information will enable the chemist to infer structural modifications that may reduce the toxicity relative to the original chemical. 

It was the sort of thing you expected in the Street of Alchemists. The neighbours preferred explosions, which were at least identifiable and soon over. They were better than the smells, which crept up on you. 

That there is some cursed item in your house that is spreading evil as the miasma of a fetid marsh spreads fever. It is a talisman in reverse, a source of misfortune instead of good. Whatever it is, it should be hunted down and destroyed. Alfeo can at least identify the source of the evil for you. ... 

Well, detective stories have other things in them besides violence and blood. They have solutions, for one thing. Almost invariably, the murderer is caught, or at the very least identified. As sure as God made little green apples, it all adds up to something. If it doesn t, we aren t happy with the piece. A good detective story ties up all the loose ends we resent motives and clues left unconnected. 

Such uncertainties relating to exposure have been acknowledged in the recently introduced contaminated land legislation (see chapter by Lowe and Lowe) which describes the need for a pollutant linkage to be identified before land can be considered contaminated. In any investigation of the potential health effects of contaminated land, it is important that viable pollutant linkages are, at least, identified and, if possible, quantified to some extent. Even where an excess of disease may exist, if a specific hazardous exposure cannot be identified then no link can be made. 

It is to the credit of earlier workers who, with limited analytical facilities and painstaking methods, were able to at least identify some of the more obvious organic compounds in seawater. The modern methods of analysis owe their development to their precursors and as such, a short historical review of alternative methods will be given for each class of compound considered. 

When a ketone reacts with a suitable base (secs. 9.1, 9.2) an enolate anion is formed by removal of the a-proton. In the case of an unsymmetrical ketone such as 30, a mixture of (Z)-enolate (31) and ( )-enolate (32) usually results (secs. 9.2.E, 9.5.A). This mixture influences the diastereoselectivity and enantioselectivity of enolate condensation reactions (sec. 9.5). Such a mixture of geometrical isomers generates both syn- and antiproducts upon reaction with aldehydes so it is important to control or at least identify the geometry of the enolate. Several solutions to this problem have been developed, including formation of stable and separable enolate isomers and controlling reaction conditions to maximize production of one isomer. 

This approach (as sketched in Fig. 2) derived from continuum solid-state physics of macroscopic metals is, however, particularly useful in our attempts to quantify, or at least identify, the various electronic regimes of interest in the problem of divided metals.f - - ... 

Developing a risk map provides a quick and easy way to identify and focus on critical risks (e.g., those in the red square, high occurrence and high impact). The next step is to rank the risks in the various squares at least in red, orange and yellow squares, so that risk intervention strategies can be developed. We present a simple risk scoring method that uses risk priority numbers (RPNs) to rank the critical risks or at least identify the top 10 or 20 risks that need attention. 

Accessibility. There is no research and development on accessibility. For a new LMFR reactor project, accesses should be provided for inspecting as many areas zones as possible, or at least, identified sensitive zones. This implies taking into account the architecture of the reactor and the characteristics of the inspection and repair processes. This task is part of the engineering design. In case of an intervention in the lower part of the reactor requiring sodiumdraining, unloading of the core would be a major preliminary operation. It should therefore be easy and fast. 

In order to validate the scenario method, the participants should at least identify the training of taking the pictures as a critical item. 

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