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Lead compound screening

The discovery that the 4-heteroarylpiperazine-l-carboxyanilide template can generate potent TRPVl antagonists was independently reported by three groups [76-79]. Most of the published work on this class of compounds was carried out by Purdue Pharma, and is focused on the optimization of (13a), a lead compound that had emerged from random screening of a chemical... [Pg.154]

The resulting compound libraries thus include many analogs of the lead compounds, which can be used in additional screens for novel leads. [Pg.70]

High-throughput screening (HTS) is today the most commonplace method for identifying lead compounds that can be subsequently optimized to generate drug candidates. [Pg.82]

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Compound screen

Lead compounds

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