Lauryl pyridinium bromide

Lauryl pyridinium bromide, surface tension, 8 244t... 

The effect of various surfactants, the cationics-eetyl trimethyl ammonium bromide (CTAB), and cetyl pyridinium chloride (CPC), the anionic-sodium lauryl sulfate (SLS), and the nonionic-polysorbate 80 (Tween 80), on the solubility and ionization constants of some sparingly soluble weak acids of pharmaceutical interest was studied (Gerakis et al., 1993). Benzoic acid (and its 3-methyl-, 3-nitro-, and 4-tert-butyl-derivatives), acetylsalicylic acid, naproxen, and iopanoic acid were chosen as model drugs. The cationics, CTAB and CPC, were found to considerably increase th< ionization constant of the weak acidS Ka ranged from-0.21 to-3.57), while the anionic, SLS, showed a negligible effect and the nonionic, Tween 80, generally decreased the ionization constants Solubility of the acids increased in aqueous micellar and in acidiLed micellar solutions. 

For bile salt mixtures, total concentration of bile salts is given. CTAB, cetyl trimethylam-monium bromide HDPC, hexadecyl pyridinium chloride lauryl taurate, sodium lauryl taurate TC-TDC, sodium taurocholate-sodium taurodeoxycholate ABS, sodium p-(H-octyl) benzene sulfonate SIC, a mixture of sodium taurocholate, sodium taurodeoxycholate, sodium taurochenodeoxycholate, sodium glycocholate, sodium glycodeoxycholate, and sodium glycochenodeoxycholate composed to resemble human small intestinal content during fat digestion and absorption (19). 

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