Latex piezoelectric immunoassay

S. Kurosawa, E. Tawara, N. Kamo, F. Ohta, and T. Hosokawa, Latex piezoelectric immunoassay detection of agglutination of antibody-bearing latex using a piezoelectric quartz crystal. Chem. Pharm. Bull. 38,1117-1120 (1990). 

M. Muratsugu, S. Kurosawa, and N. Kamo, Detection of antistreptolysin O antibody application of an initial rate method of latex piezoelectric immunoassay. Anal. Chem. 64, 2483-2487 (1992). 

H.O. Ghourchian and N. Kamo, Improvement of latex piezoelectric immunoassay detection of rheumatoid factor. Talanta 41, 401-406 (1994). 

In another study, a method for immunoassay of C-reactive protein (CRP) was developed [25], The method was designated as latex piezoelectric immunoassay (LPEIA). In this method, the frequency shift was observed using antibody bearing latex without any film on the crystal. The proposed mechanism of the frequency change is that the crystal acts as a sensor for viscosity or density changes in the solution due to aggregation of latex particles. 

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