Latex particle agglutination immunoassay

Uchida K, Gotoh A (2002) Measurement of cystatin-C and creatinine in urine. Clinica Chimica Acta 323 121-128 Umbreit A, Wiedemann G (2000) Determination of urinary protein fractions. A comparison with different electrophoretic methods and quantitatively determined protein concentrations. Clin Chim Acta 297 163-172 Viau C, Bernard A, Lauwerys R (1986) Determination of rat P2-microglobulin in urine and serum. I. Development of an immunoassay based on latex particles agglutination. J Appl Toxicol 6 185-189... 

Other homogeneous immunoassays Several further homogenous assay formats have been developed that capitalize on the ability of antigen-antibody complexes to form detectable clusters or networks. Examples include the latex particle agglutination assay and the latex particle agglutination inhibition assay, in which the analyte or the antibody is conjugated to latex beads, and the analyte is quantified by virtue of its ability to promote or disrupt agglutination. Another example is the liposome immunoassay, in which analyte molecules are coupled to lipids,... 

A large number of latex agglutination immunoassays have recently been adopted from clinical chemistry. These assays are based on the visualization of antigen-antibody complexes by the attachment of latex particles or gold colloids. Entities of this type with dimensions in the nanometer or micrometer range can be quantified by turbi-dimetry, nephelometry, light scattering techniques, and particle counters [22] - [25]. 

A relatively new type of immunoassay is based on the agglutination of coated latex particles. Research the procedure and summarize, in a few figures, how it works. What are some advantages and disadvantages of the technique ... 

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