Lateral Interactions and Their Impact on Separation in PLC

N The molecules from this category lack both the acidic and the basic functionality and, hence, they remain imable to interact through the hydrogen bonds. Aliphatic hydrocarbons are the best examples of the analytes from this particular group of compoimds. 

A These molecules are equipped with acidic functionality only and, hence, they can participate in the hydrogen bonds as proton donors. The most representative examples from this group are chloroform (CHCI3) or dichlo-romethane (CHjClj). 

B The molecules from this group incorporate electronegative (i.e., basic) heteroatoms (e.g., O, N, S, etc.) and 71-electrons, and, hence, they are able to participate in the hydrogen bonds as proton acceptors. Ketones and ethers are among the most representative classes of analytes belonging to this particular group. 

AB The molecules belonging to the last category are equipped with both the acidic and the basic functionalities and, hence, they can interact through the hydrogen bonds both as proton donors and proton acceptors. Acohols and carboxylic acids are among the most representative examples from this group. 

Analytes from class N neither self-associate nor participate in the mixed hydrogen bonds. Consequently, they cannot participate in lateral interactions of any kind, either. 

---