Large-scale isolation

Schwarz, M. et al.. Application of high-speed conntercurrent chromatography to the large-scale isolation of anthocyanins, Biochem. Eng. J., 14, 179, 2003. 

Kohler, N. and Winterhalter, R, Large-scale isolation of tlavan-3-ol fluoroglucinol adducts by high-speed counter-current chromatography, J. Chromatogr. A, 1072, 217, 2005. 

Reeves MR Eberwein RM, Rodgers LL, Testerman RR Snader KM, Forenza S. (1991) The large-scale isolation of bryostatin 1 from Bugula neritina following current good manufacturing practices. J Nat Prod 54 1265-1270. 

Van Uden W, Bos JA, Boeke GM, Woerdenbag HI, Pras N. (1997) The large scale isolation of deoxypodophyUotoxin from rhizomes of Anthriscus sylvestris followed by its bioconversion into 5-methoxypodophyUotoxin P-D-glucoside by cell cultures of Linum flavum. J Nat Prod 60 401 403. 

Large-scale production of selected hit compounds e.g. large-scale isolation or synthesis... 

THOMAS AND BARNES Large-Scale Isolation ofSr-82... 

Chen, S.E., Staba, E.J. American ginseng I. Large scale isolation of ginsenosides from leaves and stems. Lloydia 1978 41 361-366. 

Larsen, E. and Christensen, L. P. 2000. Simple method for large scale isolation of the cyclic arylhydroxamic acid DIMBOA from maize (Zea mays L ). J. Agric. Food Chem. 48, 2556-2558... 

Konrad, G., Lieske, B., and Faber, W. 2000. A large-scale isolation of native (3-lactoglobulin characterization of physicochemical properties and comparison with other methods. Int. Dairy J. 

The method can be used in large-scale isolations. However, the full effects of having polymer beads in close association with cells is still unknown, and isolation still involves the use of a MAb, which may react with target cells. IMS has enormous potential, but a fuller understanding of bead-cell interactions is currently needed. 

In order to improve the oral bioavailability, a huge number of compounds have been synthesized from artemisinin, which is a readily available naturally occurring compound [8], Large-scale isolation and purification of artemisinin from wild or cultivated Artemisia... 

Hustedt, H. Kroner, K. H. Stach, W. Kula, M.-R. "Procedure for the Simultaneous Large-Scale Isolation of Pullulanase and 1,4-a-Glucan Phosphorylase from Klebsiella pneumoniae Involving Liquid-Liquid Separations" Biotech, and Bioeng. 1978,20, pp 1989-2005. 

Raymond, G. J., Bryant, P. K., Nelson, A., and Johnson, J. D. (1988) Large-scale isolation of covalently closed circular DNA (cccDNA) using gel filtration chromatography. Anal. Biochem. 173,125-133. 

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