Large-scale-features of the human gene landscape

Large-scale-features of the human gene landscapes 

GC levels in third positions (GC3) are almost free of constraints at the protein level, while those in second positions (GC2) are almost completely determined by the gene product. Therefore, their joint distribution, or the compositional gene landscape displays relations between DNA/RNA and the proteins. 

Very large numbers of non-redundant, reliable gene sequences, which are now available for several vertebrate species, allow higher levels of resolution than were previously possible, and prompted us to analyze their landscapes (two-dimensional distributions) in more detail. We focussed on human, where a nonredundant set of 10,218 genes was available from a well-curated human sequence database. We also studied the landscapes for three other vertebrates that are represented by large sequence databases, namely mouse, chicken and Xenopus (Cruveiller et al., 2004b). The warm-blooded vertebrate landscapes are adequately described by a structure of peaks and valleys along the landscapes crests, whereas the Xenopus landscape only shows a short crest with two peaks. 

Gene landscapes correspond to e.xperimentally determined DNA land.scapes 

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