LAM and Related Glycoconjugates

The fine structure of mycobacterial LAM with a range of structural diversity is generally well understood (Fig. 14.8) [257, 258], The core structure of LAM is composed of a phosphatidylinositol moiety connected to a mannan domain consisting of u( 1 - 6)- and a(l - 2)-linked mannopyranose residues. The mannan domain is linked to arabinan composed of (1 — -5)-, a(l- 3)-, and p(l- 2)-linked arabinofuranose 

Lowary et al. synthesized oligomannoside derivatives to find out the optimal length required by (l 6)-mannosyl transferase for LAM biosynthesis [267, 268] and the specificity of a(l - 4)-mannosy I transferase involved in mycobacterial methylmannose polysaccharide biosynthesis [269], Oligoarabinofuranosides containing C3-modified Ara/residues were also synthesized as the inhibitor of arabinofuranosyltransferases from mycobacteria [270], 

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