Lahav

Lahav, M. and Leiserowitz, L., 2001. The effect of solvent on crystal growth and morphology. Chemical Engineering Science, 56(7), 2245-2254. 

Jacquemain D, Grayer-Wolf S, Leveiller F, Lahav M, Leiserowitz L, Deutsch M, Kjaer K, Als-Nielsen J (to be published)... 

Tremblay, C., Barza, M., Szoka, F., Lahav, M., and Baum, J. (1985). Reduced toxicity of liposome-associated amphotericin B injected intravitreally in rabbits. Invest. Ophthalmol. Visual Sci., 26, 711-16. 

Weissbuch I, Leiserowitz L, Lahav M (2005) Stochastic Mirror Symmetry Breaking via Self-Assembly, Reactivity and Amplification of Chirality Relevance to Abiotic Conditions. 259 123-165... 

Addadi L, Lahav M (1979) in Walker DC (ed) Origins of optical activity in nature. Elsevier, New York, chapt 14... 

The importance of this sensational discovery for biogenesis research only became apparent in the next few years (Lahav, 1999). It is clear that prebiotic chemistry is much more complex and versatile than was thought about 50 years ago, when Stanley Miller carried out his first successful amino acid syntheses. Experiments similar to the ones described above, as well as new ones which must first be devised, could help to slowly close the wide gap which still exists between the prebiotic and the living worlds (Wills and Bada, 2000). 

Lahav N (1999) Biogenesis. Oxford University Press, New York, Oxford, p 230... 

According to Lahav (1999), the complete process can be summarized as follows ... 

In a self-reproducing, catalytic hypercycle (second order, because of its double function of protein and RNA synthesis) the polynucleotides Ni contained not only the information necessary for their own autocatalytic self-replication but also that required for the synthesis of the proteins Ei. The hypercycle is closed only when the last enzyme in the cycle catalyses the formation of the first polynucleotide. Hypercycles can be described mathematically by a system of non-linear differential equations. In spite of all its scientific elegance and general acceptance (with certain limitations), the hypercycle does not seem to be relevant for the question of the origin of life, since there is no answer to the question how did the first hypercycle emerge in the first place (Lahav, 1999). 

Later articles dealt with further elaboration of ideas on the driving forces which would have led to the formation of higher aggregates from RNA and amino acids. As had been suggested 20 years earlier, these processes could have taken place in rock pores and could have been driven by hydration and dehydration phases (Kuhn and Waser, 1994). The tiny pores in rocks act as minute test tubes, so optimal compositions could have been determined and replicated using many millions of systems. According to this model, none of the synthetic processes taking place would have required the presence of protein enzymes (see also Lahav, 1999). Just as other... 

These experimental results could not be confirmed by Lahav and co-workers they suggest that impurities in the starting materials have a much greater effect on the crystallisation process than the PVED (Parity Violating Energy Difference). Extensive experimental studies indicate the importance of small quantities of impurities, particularly in early phases of crystallisation nucleus formation. Amino acids from various sources were used, and the analyses were carried out using the enan-tioselective gas chromatography technique (M. Lahav et al 2006). 

Lahav M, Weissbuch I, Shavit E, Reiner C, Nicholson J, Schurig V (2006) Orig Life Evol Biosphere 36 151... 

Bar J, Lahav J, Hod M, Ben-Rafael Z, Weinberger I, Brosens J (2000) Regulation of platelet aggregation and adenosine triphosphate release in vitro by 17beta-estradiol and medroxyprogesterone acetate in postmenopausal women. Thromb Haemost 84 695-700... 

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