Lactic acid, incompatibilities with

Peptide mimetics containing the a-ketoamide moiety are very important because they act as cysteine protease inhibitors. In fact, the a-ketoamide residue forms hemithioacetals with the -SH group of the cysteine residue of the enzyme [32], Nakamura et al. [26b] reported the preparation of a 100-member combinatorial library of a-ketoamides by means of a two-step one-pot synthesis. The first step consisted of the Ugi-4CR between (+/— )lactic acid, amines, isocyanides, and aldehydes leading to the formation of the lactamides 40 which were oxidized to the corresponding pyruvamides 41. This one-pot procedure was performed in THF since the PDC oxidation was incompatible with the presence of methanol. Five a-ketoamides showed an 80% average purity (Scheme 2.17). 

LACTIC ACID, ETHYL ESTER (97-64-3) CjHioOj Forms explosive mixture with air [explosion limits in air (vol %) 1.5 to 11.4 flashpoint 115°F/46°C cc autoignition temp 752°F/400°C Fire Rating 2]. Contact with strong oxidizers may cause fire and explosions. Incompatible with nitrates alkalis or acids (either can generate high heat). Contact with alkali metals and hydrides liberates flammable hydrogen gas. On small fire use dry chemical, alcohol-resistant foam, or COj extinguishers. LACTOBARYT (7727-43-7) see barium sulfate. 

LACTIC ACID, BUTYL ESTER (138-22-7) Combustible liquid (flash point 160°F/ 71°C). Incompatible with strong oxidizers, strong bases, acids. 

LACTIC ACID, ETHYL ESTER (97-64-3) Forms explosive mixture with air (flash point 115°F/46°C cc). Contact with strong oxidizers may cause fire and explosions. Incompatible with nitrates. 

RACEMIC-LACTIC ACID (598-82-3) Aqueous solution is an organic acid violent reaction with caustic materials, fluorine, potassium permanganate. Incompatible with oxidizers, sulfuric acid, ammonia, aliphatic amines, alkanolamines, isocyanates, alkylene oxides, epichlorohydrin. 

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