Lactate transporters

Donovan, J.A., and Jennings, M.L. (1986) N-Hydroxysulfosuccinimido active esters and the L-( + )-lactate transport protein in rabbit erythrocytes. Biochemistry 25, 1538-1545. 

McKenna, M. C., Tildon, J. T., Stevenson, J. H. etal. Lactate transport by cortical synaptosomes from adult rat brain Characterization of kinetics and inhibitor specificity. Dev. Neurosci. 20 300-309,1998. 

A. Aim and P. Tornquist. Lactate transport through the blood-retinal and the blood-brain barrier in rats. Ophthalmic. Res. 17 181-184 (1985). 

Deficiency of pyruvate dehydrogenase is the most frequent cause of lactic acidemia ac Since this enzyme has several components (Fig. 15-15), a number of forms of the disease have been observed. Patients are benefitted somewhat by a high-fat, low-carbohydrate diet. Transient lactic acidemia may result from infections or from heart failure. One treatment is to administer dichloroacetate, which stimulates increased activity of pyruvate dehydrogenase, while action is also taken to correct the underlying illness.d Another problem arises if a lactate transporter is defective so that lactic acid accumulates in muscles.6... 

Lactate and pyruvate seemed to be the endogenous substrates with the highest affinity to MCTs at the BBB, whereas other monocarboxylates such as acetate, propionate, and butyrate were transported to a lower extent [93, 106]. This is consistent with BBB uptake studies published by Oldendorf [107]. Moreover, stereoselectivity of MCTl for L-lactate transport was shown toward the D-isomer in studies carried out by Broer et al. [93, 94]. 

Broer. S.. Rahman, B Pellegri, G Pellerin, L., Martin, J,L, Verleysdonk, S., Hamprecht, B., and Magistretti, P,J, (1997) Compar ison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCTl) expressing Xenopus laevis oocytes expression of two different monocarboxylate transporters in... 

De Bruijne, A.W., Vreeburg, H., and Van Steveninck, J. (1983) Kinetic analysis of L-lactate transport in human erythrocytes via the monocarboxylate-specific carrier system. Biochimica et Biophysica Acta, 732, 562—568. 

Jackson, VN. and Halestrap, A.P. (1996) The kinetics, substrate, and inhibitor specffidty of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2 7 -bis(carboxyethyl)-5(6)-carboxyfluorescein. The Journal of Biological Chemistry, 271, 861—868. 

JEN1 Lactate transporter, required for uptake of lactate and pyruvate ... 

Wu X, Alshawabkeh AN, Gent DB, Larson SL, Davis JL. (2007). Lactate transport in soil by DC fields. Journal of Geotechnical and Geoenvironmental Engineering 133 ... 

R340 C. R. Figley, Lactate Transport and Metabolism in the Human Brain Implications for the Astroc5de-Neuron Lactate Shuttle Hypothesis , J. 

Inhibition of lactate transport Quercetin, morin fisetin, and related compounds 3-4 X 10" M 6... 

Draoui, N. Schicke, O. Fernandes, A. Drozak, X. Nahra, F Dumont, A. Douxfils, J. Hermans, E. Dogne, J. Corbau, R. Marchand, A. Chaltin, R Sonveaux, R Feron, O. Riant, O. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg. Med. Chem. 2013, 21,... 

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