Lachnum papyraceum Lachnumone

Stadler M et at. New metabolites with nematicidal and antimicrobial activities from the ascomycete Lachnum papyraceum (Karst.) Karst. VII. Structure determination of brominated lachnumon and mycorrhizin A derivatives, J Antibiot 48 158-161, 1995. 

The germination of the monocotyle Setaria italica and the dicotyle Lepidium sativum is inhibited by the mycorrhizins, e.g. 123, lachnumon (124), and halogenated isocoumarin derivatives, like 125, which have been isolated from the ascomycete Lachnum papyraceum [98]. 

Stadler M, Anke H, Sterner O (1995) Metabolites with Nematicidal and Antimicrobial Activities from the Ascomycete Lachnum papyraceum (Karst.) Karst V. Production, Isolation and Biological Activities of Bromine-Containing Mycorrhizin and Lachnumon Derivatives and Four Additional New Bioactive Metabolites. J Antibiot 48 149... 

The structures of four new biologically active nematocidal halogenated dihydroisocoumarins (162-165) isolated from submerged cultures of the wood-inhabiting ascomycete Lachnum papyraceum have been elucidated by spectroscopic methods. The compounds are structurally related to lachnumon and mycorrhizin A, which are also produced by the fungus [198],... 

The structure determination of lachnumon (193), brominated derivatives of lachnumon (194) and mycorrhizin (195) and brominated derivatives of mycorrhizin A (196) was described. The compounds, which exhibit similar antimicrobial and nematocidal activities as their chlorinated analogues, were isolated from extracts of cultures of the ascomycete Lachnum papyraceum to which CaBr2 had been added [219]. 

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