Lacey-Dieckmann cyclization

The total synthesis of fuligorubin A (78) has been described and is based on the Lacey-Dieckmann cyclization [130b, 157]. 

Synthesis of physarorubinic acid, which is a polyenoyltetramic acid plasmodial pigment, is another example. The synthesis uses a Lacey-Dieckmann cyclization starting with ester 51, followed by deprotection to give physarorubinic acid (52) in 78% yield for the two steps. ... 

The most frequently used strategy for making acyl- and polyenoyltetramic acids is by the Lacey-Dieckmann cyclization of p-ketoamides, whose nitrogen... 

FIG. 7 Western building blocks past (Tines 2-3 ) and present (line 1) set up to for chain length increase and a subsequent Dieckmann cyclization—or so-called Lacey-Dieckmann condensations—to give polyenoylteramic acids. 

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