Lacey-Dieckmann condensation

Our western building block 30 fulfilled three design principles (Fig. 6). First, 30 is a progenitor of an acyltetramic acid motif upon deprotonation of its (enolized) p-ketoamide moiety and a ring-forming acylatimi. This cycliza-tion is dubbed a Lacey-Dieckmann condensation in the Second, 30... 

FIG. 7 Western building blocks past (Tines 2-3 ) and present (line 1) set up to for chain length increase and a subsequent Dieckmann cyclization—or so-called Lacey-Dieckmann condensations—to give polyenoylteramic acids. 

---