L-Methadone

Several narcotic antagonists, including naloxone, naltrexone, L-methadone, and cyclazocine, have been incorporated in lactide homopolymers and lactide/glycolide copolymers. Cyclozocine was incorporated in poly(L-lactide) in the form of films (81,82). Lamination of drug-polymer films with a drug-free film created a reservoir device and eliminated the burst observed with the monolithic films originally tested. 

Cha, Y., and Pitt, C. C., A one-week subdermal delivery system for L-methadone based in biodegradable microspheres,... 

Fischer BD, Carrigan KA, Dykstra LA Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and L-methadone-induced antinociception in mice. 3 Pain 2005 6 425. [PMID 15993820]... 

Mercadante S, Casuccio A, Agnello A, Barresi L. Methadone response in advanced cancer patients with pain followed at home. J Pain Symptom Manage 1999 18(3) 188—92. 

The analgesic activity of the racemate is almost entirely the result of its content of L-methadone, which is 8 to 50 times more potent than the d isomer D-methadone also lacks... 

Carbon 2 of methadone is asymmetric and hence there are three compounds to be considered the racemic di-methadone, d-methadone and l-methadone. Z-Methadone accounts for the addiction liability and analgesic effect of the racemic mixture. d-Methadone is inactive in respect to analgesia and addiction liability. Methadone has been used as a specific name for the racemic mixture. 

Identification of Glucuronide Metabolites of D- and L-Methadone in Bile from the Isolated Perfused Rat Liver... 

Fig. 8.2 Two-dimensional structures of l-methadone and the enol tautomer of l-methadone together with three-dimensional space-filling baU-and-stick (la, c and 2a, c) and CPK models (lb, d and 2b, d) for l-methadone and its enol tautomer, respectively. The models of l-methadone show one of many possible conformations while the models of the enol form show the molecule locked by the intramolecular...

H26N2O11 f 14R, 16S-De(vindolinyl)catharinine, 44B, 536 H2 7BrN20i, Strychnine hydrobromide dihydrate, 15, 497 H27CIN2O3, Yohimbine hydrochloride, 39B, 422 H27NO, L-Methadone, 40B, 44 H27NO, Methadone, 39B, 422... 

---