8-L-lysine vasopressin

ADH, a nonapeptide, released from the posterior pituitary gland promotes re-absorption of water in the kidney. This response is mediated by vasopressin receptors of the V2 subtype. ADH enhances the permeability of collecting duct epithelium for water (but not for electrolytes). As a result, water is drawn from urine into the hyperosmolar inter-stitium of the medulla. Nicotine augments (p. 110) and ethanol decreases ADH release. At concentrations above those required for antidiuresis, ADH stimulates smooth musculature, including that of blood vessels ( vasopressin ). The latter response is mediated by receptors of the Vi subtype. Blood pressure rises coronary vasoconstriction can precipitate angina pectoris. Lypres-sin (8-L-lysine vasopressin) acts like ADH. Other derivatives may display only one of the two actions. 

Lypressin (8-L-lysine-vasopressin) acts like AVP. Other derivatives may display only one of the two actions. 

RECEPTOR AGONIST or 5-HYDROXYTRYPTAMINE RECEPTOR ANTAGONIST (5-HT, , S-HTj and others). It has SYMPATHOMIMETIC actions. It is a drug of abuse, and was formerly used in psychotherapy as PSYCHOTROPIC AGENT, lysine vasopressin lypressin vasopressin. 8-L-lysine vasopressin vasopressin. 

Chemical Name Vasopressin 2-(L-phenylalanine)-8-L-lysine Common Name —... 

Pickup, J. C., Johnston, C. I., Nakamura, S., Uttenthal, L. O., and Hope, D. B., 1973, Subcellular organization of neurophysins, oxytocin, [8-lysine]-vasopressin and adenosine triphosphatase in porcine posterior pituitary lobes, Biochem. J. 132 361. 

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