L- indene

The lithium-(-)-sparteine complex, generated by deprotonation of 1-methylindene, does not lose its configuration in diethyl ether solution even at room temperature80 presumably, the observed major diastcreonier is the thermodynamically determined product. Substitution with carbonyl compounds leads to 1-substituted (fl)-l-methyl-l//-indenes with >95% ee in high yields81. 

A mixture of 2.0 mmol of a 1.6 N solution of butyllithium in hexane and 0.47 g (2.0 mmol) of(-)-spartcinc in 10 mL of diethyl ether is stirred for 15 min at — 78 rC then 0.26 g (2.0 mmol) of 1-methyl-l//-indene in 2 mL of diethyl ether are added. Stirring is continued for 30 inin at 20 °C, the mixture is cooled to — 70 CC and 2.5 mmol of the acid chloride in 2 mL of diethyl ether are added. After stirring for 4h the usual aqueous workup was accomplished by addition of 10 mL of diethyl ether and successive washing with 10 mL of 2 N aq HC1. water and sat. aq NtiCl, respectively, followed by chromatographic purification on silica gel with diethyl cthcr/pentane. 

Methyl ( )-2,3-Dihydro-l-oxo-2-(3-oxobutyl)-l//-indene-2-carboxylate (2) Typical Procedure259 ... 

Sodium metaperiodate [Metapenodic acid, sodium salt], 55, 68 Sodium, toluene dispersion of, 55, 65 Spiro[cyclopentane-l,l -indene], 55, 94 CE) Stilbene [Benzene, 1,1 (1,2-ethenediyl)-bis-], 55,115... 

Benzenediamine (560) and l-diphenylamino-l,2,3,4-tetrahydroindeno[l,2-/tjpyrrole (561) in dichloromethane containing a trace of hydrogen chloride at 20°C during 48 h afforded 3-(l-diphenylhydrazono-2,3-dihydro-l//-inden-2-yl)-2(l//)-quinoxalinone (562) in 53% yield. 

CN (Z)-5-fluoro-2-methyl-l-[[4-(methylsulfinyl)phenyl]methylene]-l//-indene-3-acetic acid... 

C7H22N2 140-80-7) see Chloroquinc Mepacnne 7(77)-amino-3-[[(2,5-dihydro-6-hydroxy-2-methyl-5-oxo-l,2,4-triazin-3-yl)thio]mcthyl]-3-cephem-4-carboxylicadd (C12H13N5O5S2 58909-56-1) see Ceftriaxone (15-franx)-l-amino-2,3-dihydro-l//-inden-2-ol (CyH NO 163061-74-3) see Indinavir sulfiite cis-l-amino-2,3-dihydro-l//-inden-2-ol (C9H11NO 7480-35-5) see Indinavir sulfate... 

C jH2,NOSi) see Indanorex (lS-cii)-2,3-dihydro-l//-indene-l,2-diol (G7H10O2 6752S-22-7) see Indinavir sulfate (laS)-la,6a-dihydro-6//-indenori,2-6]oxirene (CgHjO 67528-26-1) see Indinavir sulfate (2,3-dihydro-l//-inden-4-yl)carbamimidothioic acid methyl ester monohydriodide (C, H 1N2S 40507-77-5) see Indanazoline 23-dibydro-l//-indole-2-carboxylic acid ethyl ester (C iH, N02 50501-07-0) see Perindopril... 

CcjHu 95-13-6) see Indinavir sulfate [(l//-inden-4-yloxy)methyl]oxirane (C,2H 202 64966-57-0) see Indenolol [(lf/-inden-7-yloxy)methyl]oxirane... 

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