L,3-dihydroxy propane

Anilino-2-metbyl-l,3-propanediol or 2-Pbenylamino-2-metbyl-l,3-dihydroxy-propane, C6H5 -NH-CfCH, XCH, OH), may be considered as the parent compd of derivs listed below ... 

Dioxo-l,3-diaryl-propane dimerisieren reduktiv zu 3,4-Dihydroxy-1,6-dioxo-1,3,4.6-tetra-aryl-hexanen I, 1,3,5,6-Tctraaryl-2,4,7-trioxa-tricyclo[3.2.1.13 6]n0nanen II und 1,2,4-Trihydroxy-l,2,4-triaryl-3-aroyl-cyclopentancn III4 ... 

C-tracer experiments with 1,3-dihydroxy-l-(4-ethoxy-3-methoxyphe-nyl)-2-[U-ring-13C](2-methoxyphenoxy)propane and l,3-dihydroxy-l-(4-ethoxy-3-methoxyphenol)-2-[U-ring-13C](2,6-dimethoxyphenoxy)propane as substrates confirmed that the products were ring cleavage products. 

Eine interessante Variante dieser Synthese ist die Herstellung von 4(5 j -Hydroxymethyl-imidazol aus Fructose28-31a 31b. Dabei unterliegt Fructose unter dem EinfluB der Base Ammoniak zu-nachst einer Retro-Aldol-Reaktion zu l,3-Dihydroxy-2-oxo-propan, das dann mit Ammoniak, Formaldehyd und Kupfer(II)-acetat zu 4(5)-Hydroxymethyl-imidazol weiterreagiert. 

Heptryl. See 2-(2 ,4 ,6 -Trinitro-N-nitranilino)-2-nitrotymethyl-l, 3-di-nitroxypropane under 2-Anilino-2-hydroxymethyl-1,3-dihydroxy-propane in Vol 1, p /A441 See ADDENDUM, p ni in this Vol... 

Ami no-1,3-prop anedi ol (Glycerol- monoamine, fj-Aminotrimethyleneglycol, 2-Amino-l, 2-dihydroxy propane or 2-Aminopropane-... 

An equimolar mixture of dihydroxyacetone phosphate and 2,3-dihydroxy-propanal is converted in the presence of PAN-immobilized aldolase (7 U/mmol), in quantitative yield, into an equimolar mixture, after dephosphatation, of D-fructose and L-sorbose (see Scheme 7).31 This is what would... 

Figure 1. XANES spectra for crystallographically characterized Mn(II), Mn(III), and Mn(IV) model compounds. Long dashed lines indicate Mn(II) compounds solid lines indicate Mn(III) compounds short dashed lines indicate Mn(IV) complexes. The models chosen to illustrate this phenomenon are[Mn(ll)HB(3,5-iPr2pz) 3]2(OH) 2and(pyrazolyl) 2Mn(OCfi3) 3Mn(ll) (HB 3,5-iPr2pz)3 [where HB(3,5-iPr2pz)3 is hydrotris(3,5-diisopropyl-1-pyrazolyl borate) Mn(II)(hexakisimidazole)Cl2 Mn(III)(acac)3 Mn(III)2, [2-OH-(5-Cl-SAL)PN]2(CH3OH), [Mn(IV) (n2-0) (SALPN)]2, and [Mn(IV)-(SALPN)]2(h2-0)(h2-OH) [where SALPN is l,3-bis(salicylideneimanato) propane] [Mn(III) (SALAHP) (AcO)]2 [where SALAHP is 3-(salicylideneim-inato)-2-methyl- 1,3-dihydroxy propane] and Mn(IV) (SALADHP) 2 [where SALADHP is the dianion of 2-methy 1-2-(salicylideneamino)-1,3-dihydroxy-propane].

Cyclopentan cw-2,2-Dichlor-l, 3-dihydroxy- iV/ld, 309 Propan l-Acetoxy-2,3-dichlor- V/3, 777... 

Trinitrophenylamino)l,3-propanediol or 2-(2, 4, 6 -Trinitrophenylamino)-1,3-dihydroxy-propane (OjN)jC Hj.NH.CH-(CH,OH) mw 302.20, N 18.54%. Yel solid, mp 150 insol in petr eth, chlf, CCI4 benz sol in w, ale, acet NB. Can be prepd by boiling an ale soln of 2-amino-l,3-propanediol with 2,4,6-trinitrochlorobenzene in the presence of Na acetate. It exploded on heating or on impact but milder than its higher nitrated product described below... 

The solubility of antibiotic chloramphenicol (2,2-dichloro-N-[l,3-dihydroxy-l-(4-nitrophenyl) propan-2-yl]acetamide) in water is relatively low ( 2.5 g/L at 25 C). Therefore, to prepare chloramphenicol/silica composites, the impregnation method was used (Krupska et al. 2006). The LT H NMR spectroscopy study of these composites showed that the free surface energy Ys of interfacial water decreases with increasing amount of chloramphenicol in the composition (Figure 1.165, curve 1). This can be interpreted as displacanent of water from the silica surface by the drug molecules. However, despite the maximal amount of chloramphenicol (1 mmol/g) greater than the content of surface silanols (Cqh 0.6-0.7 mmol/g for A-300 samples), the perturbation... 

As a model system, experiments were carried out using (3S)-l,3-dihydroxypentan-2-one 14, which arises from the reaction of propanal with Li-HPA in the presence of E. coli TK. Addition of excess tetrazohum red and sodium hydroxide solution led to a development of a red color within 2 min because of the formation of formazane concomitantly with the diketone. The intensity displayed increased with rising concentrations of 14. According to measurements carried out at 485 nm 14 was detectable down to a corresponding bioconversion of 2.5 mM. As an alternative product from carbohgation to benzaldehyde, l,3-dihydroxy-3-phenylpropan-2-one 15 was also tested in the assay, and comparable levels of detection were determined. 

CJFormaldehyde and nitromethane react analogously. With two equivalents of H CH0, for example, l,3-dihydroxy-2-nitro[l,3- C2]propane (113) was formed. 

Amino-2-metbyl-1 -propanediol 2-Ammo-2-meibyl-l, -dihydroxy-propane or Bis(hydroxymethyl )metbyl-aminometbane called in Beil /3-Amino-j8-methyl-trimethylenglykol), HO-CH,—C(NH )-CH. OH ... 

Garzon-Aburbeh, A., et al. 1986. A lymphotropic prodrug of L-dopa Synthesis, pharmacological properties, and pharmacokinetic behavior of l,3-dihexadecanoyl-2-[(S)-2-amino-3-(3,4-dihydroxy-phenyl)propanoyl]propane-l,2,3-triol. J Med Chem 29 687. 

The stereoselectivity obtained with the PPFA ligand is generally higher than that obtained with (2,3-0-Isopropylidene)-2,3-dihydroxy-l,4-bis(diphenylphosphino)buta ne (DIOP) (7-16% ee), l,2-bis(diphenylphosphino)propane (prophos) (0% ee), and 2,2 -bis(diphenylphosphinomethyl)-1,1 -binaphthyl (NAPHOS) (11% ee). 

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