L- cycloheptene

The course of alkylation is also influenced by the steric arrangement of the enamine. 1-Pyrrolidino-l-cycloheptene gave approximately equal quantities of the C- and N-alkylated products in dioxane, while 1-pyrroli-dino-l-cyclooctene, and 1-pyrrolidino-l-cyclononene afforded N-alkylated products exclusively under similar eonditions (29). The reason for N alkylation in the eight- and nine-membered ring compounds is to be found in the conformation of these rings, which prevents full interaction of the unshared electrons on nitrogen with the n eleetrons of the double bond. 

Ethyl nitrite, 58,113,115 ETHYL 7-3-NITROACRYLATE, 56,65 Ethyl JV-nitroso-JV-(p-tolylsulfonylmethyl> carbamate, 57, 96 Ethyl nonanoate, 59, 110 Ethyl 7-oxo-l-cycloheptene-l-carboxylate,... 

Transimination Pure l-aza-l-cycloheptene was introduced in a NMR probe at a known concentration and primary amine was gradually added. The equilibrium was determinated by iH and 13C NMR analysis. 

Diamine 8 is obtained from hydrogenation of amino imine 7 which can be formed by direct addition of primary amine to amino imine [1] or to l-aza-l-cycloheptene 3. 

Diphenyl-l,2-diaza-l-cycloheptene (98) undergoes a similar type of ring contraction, accompanied by the formation of nitrogen, on exposure to UV light.79 In the solid state, this photolysis is stereospecific and the product is cis-1,2-diphenylcyclopentane (99). Both thermal and photolytic decompositions in solution yield a mixture of cis- and trans-1,2-diphenylcyclopentane in addition to cis- and... 

Alkyl- A Lpiperideines and 2-alkyl-1-aza-l-cycloheptenes are formed in good yields on treatment of imino-ethers with a Grignard reagent149,150 (Eq. 1). 

From a preparative point of view, the course of the alkylation can be undesirably influenced by the structural arrangement of the starting enamine. Thus, treatment of 1-pyrrolidino-l-cycloheptene with ethyl iodide, followed by hydrolysis, gives about 40% of 2-ethylcyclo-... 

Fourteen seven-membered ring compounds have been tritium-labelled by AcT, AdT or HTI methods165 including ( )3,3,5-trimethylhexahydroazepine—162, 2-oxohex-amethyleneimine (caprolactam)—163, l-aza-2-methoxy-l-cycloheptene—164, 1,4-dia-zacycloheptane (homopiperazine)—165, l,8-diazabicyclo-[5.4.0]undec-7-ene—166, 5H-dibenzo[6j/]azepine (iminostilbene)—167, 8-chloro-l 1-(4-methyl-l-piperazinyl)5//-... 

A similar reaction carried out with cyclohexene led to the formation of 3-methoxycyclohexene When this reaction sequence is carried out with internal olefins, the methoxyalkyl phenyl tellurium oxides are not stable and decompose to methoxyalkenes in the basic medium required for the hydrolysis of the methoxyalkyl phenyl tellurium dibromides(see p. 583). Aqueous solutions of sodium hydrogen carbonate cause the same transformations at a slower rate". Thus, 5-hydroxy and 5-methoxy-4-hexyl phenyl tellurium dibromide were converted to the corresponding 5-substituted 3-hexenes. 3-Hydroxy- and 3-methoxy-l-cycloheptene were similarly obtained. ... 

Methylcapro1actim, (l-aza-2-methoxy-l-cycloheptene), is available from the Janssen Chimica Society (France) and from the Aldrich Chemical Company, Inc, It may be also prepared from s-caprolactam and dimethyl sulfate. ... 

Willstatter s method (Volume I, pp. 278 285-286) to a-methyltropidine, i.e. (+ )-5-dimethylamino-l,3-cycloheptadiene (LXXXIV). Resolution of the latter with dibenzoyltartaric acid followed by (a) isomerization of each antimer into )3-methyltropidines (LXXXV), (b) hydrolysis, (c) partial hydrogenation of the cycloheptenone, and (d) Grignard reaction with the cycloheptanones (LXXXVI) gave the phenyl-, and p-chlorophenyl-l-cycloheptenes (LXXXVII). The product of oxidation, arising from (+ )-LXXXI V, contained the whole radioactivity, while the benzoic and p-chlorobenzoic acids from the levorotatory form were radioinactive. This proved that the whole label from ornithine-a-i C was either in C-1 or in C-5 in hyoscyamine (80, 81). 

Appropriate nitro-allyl derivatives for condensation to hexatrienes are usually not easily available, with the exception of nitromethyl-l-cyclohexene and nitro-methyl-l-cycloheptene (34)43. Like nitromethane, 34) does not condense with vinamidinium salts (7) and sodium methoxide, but yields insoluble sodium salts. 

Nortriptyline Hydrochloride is 10,11-dihydro-N-methjl-5H-dibenzo [a,d"l-cycloheptene-, Y -propylamine hydrochloride1. It is also known as 5H-dibenzo La,d] cycloheptene-A, V ipropylamine, 10,11-dihydro-N-methyl hydrochloride2. It is known as 5-(of-methylamino propylidene)-dibenzo Ca,d] cyclohepta[l, +1 diene hydrochloride and 3-(lO,ll-dihydro-5H-dibenzo[a,d1 cyclophetene-5-ylidene)-N-methyl propylamine hydrochloride. Common names for the compound are desitriptylina and desmethylamitriptyline hydrochloride. ... 

Preparation of 4-aza-5-(N-methyl-4-piperidylidene)-10,11-dihydro-5H-dibenzofa,d] cydohep-tene dimaieate To a solution containing 4.3 g of 4-aza-(N-methyl-4-piperidvlidene)-10,11-dihydro-5H-dibenzo[a,d] cycloheptene in 55 ml of ethyl acetate, add a solution of 3.45 g of maleic acid dissolved in ethyl acetate. Filter the resulting precipitate and recrystallize the desired product from an ethyl acetate-methanol mixture to yield 4-aza-5-(N-methyl-4-pi-peridvMdene)-10,11-dihydro-5H-dibenzo[a l] cycloheptene dimaieate, MP 152°-154°C. 

Preparation of 5-l3-Methylaminopropyl)-5H-Dibenzo[a,djCycloheptene from 5-[3-(N-Formyl-N-Methylj-Amlnopropyl]SH-Dibenzo[a/l]Cycloheptene 29.5 grams of 5-(3-(N-formyl-N-methyD-aminopropyl] -5H-dibenzo(a,d] cycloheptene is refluxed for 24 hours under nitrogen in a Solution of 36.3 grams of potassium hydroxide in 378 ml of n-butanol. After cooling to room temperature, the solvent is evaporated in vacuo, the residue Is stirred with 200 ml of water, 300 ml of n-hexane, the layers separated, the water layer extracted with 100 ml of n-hexane and the combined hexane layers washed with water (2 x 100 ml) and then with... 

Synonyms 5-(l-Cyclohepten-l-yl)-5-ethyl-2,4,6(lH,3H,5H)-pyrimldinetrione 5-ethyl-5-cycloheptenylbarbituric acid Trade names Heptadorm, Medomin... 

Methyl propiolate and triethylamine added to refluxing 3 -hydroxy-4, 5 -di-methoxy-l,2-benzo-l-cyclohepten-4-one in abs. benzene-terf-pentanol, refluxed 45 min., K-fert-butoxide soln. added, and refluxing continued for 30 min. -> hydroxydimethoxy-2-pyrone derivative. Y over 70%. Also isolation of intermediates s. J. Schreiber et al., Helv. 44, 540 (1961). 

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