L-chicoric acid

Several studies published since March 1996 have expanded the list of in vitro integrase inhibitors effective at IC50 values below 100 pM. These include two dicaffeoylquinic acids obtained from medicinal plants and a synthetic analog, L-chicoric acid [68], the HIV protease inhibitors NSC 117027 and NSC 158393 [69], certain anthraquinone derivatives [70], coumermycin, and pyridoxal phosphate [71]. In addition to exhibiting in vitro inhibition, the dicaffeoylquinic acids effectively inhibited HIV-1 replication in T-lymphoblastoid cell lines [68]. 

Fungal products Dicaffeoyiquinic and dicaffeoyltaric acid, L-chicoric acid, and a... 

Lamidey, A., Fernon, L., Pouysegu, L., Delattre, C., Quideau, S., and Pardon, P. 2002. A convenient synthesis of the Echinacea-derived immunostimulator and HIV-1 integrase inhibitor (— )-(2S, 3R)-chicoric acid. Helv. Chim. Acta 85, 2328-2334. 

Scarpati, M. L., and G. Oriente Chicoric acid (dicaffeyltartic acid) its isolation from chicory (Chicorium intybus) and synthesis. Tetrahedron 4, 43—48 (1958). 

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