L-Butyl-4-methyl

Discriminative stimulus effect. Rhesus monkeys, trained to discriminate A-9-THC from vehicle in a two-lever drug discrimination procedure, were tested with a variety of psychoactive drugs, including cannabinoids or drugs from other classes. The results indicated that A-9-THC discrimination showed pharmacological specificity, in that none of the noncannabinoid drugs fully substituted for A-9-THC. The classical cannabinoids, A-9-THC and A-8-THC, and the novel cannabinoids, WIN and l-butyl-2-methyl-3-(l-naphthoyl)indole, produced full dose-dependent substitution for A-9-THC in all monkeys. A heptyl indole derivative failed to substitute for A-9-THC, but it also did not displace pH] CP-55,940 from its binding site . ... 

N-(l -Butyl-2-methyl-3-butenyl)-E16a, 45 (Oxim-Red. Allyl-Add.) E21b, 1903 [H9C4-CH-N-OH + H3C-CH = CH-CH2-B(OR)2] N-Cyclohexyl-0-isopropyl-E16a, 276 (Oxitn-Red.)... 

Figure 15 Molecular structure of ( -allyl)-(> -l- -butyl-2-methyl-l,2-azaborolyl)dicarbonylmolybdenum.

Isoamyl acetate (l-butyl-3-methyl acetate) [123-92-2] 1.40535. Dried with finely divided K2CO3 and fractionally distd. 

Isoamyl ether [diisopentyl ether, di-(l-butyl-3-methyl) ether] [544-01-4] M 158.3, b 173.4 , d 0.778, n 1.40850. This is a mixture of 2- and 3-methylbutyl ether. It is purified by refluxing with sodium for 5h, then distilled under reduced pressure, to remove alcohols. Isoamyl ether can also be dried with CaCl2 and fractionally distd from P2O5. 

MONOALKYLATION OF a.p-UNSATURATED KETONES via METALLOENAMINE8 l-BUTYL-10-METHYL-Ai< -2-OCTALONE... 

As a second exanple, consider the preparation of l-bromo-2-methyl-2-propanol from rcrr-butyl alcohol. 

A recent variation of these reactions uses 6/f-l, 3-oxazin-6-ones as the electron-deficient heterodiene in place of the triazine.113114 With cyclopropene at — 35 C oxazinone 45 furnishes the 4//-azepine 46 in excellent yield. Likewise, with 3-methylcyclopropene the 4-methyl derivative 46 (R = Me) is formed. Cycloaddition with 1-methylcyclopropene, however, generates a mixture of 7-tert-butyl, 2-methyl 3-methyl- and 5-methyl-4//-azepine-2,7-dicarboxylate in a 2 1 ratio and a 97 % overall yield. 

Propanethiol, 1-propanethiol, 1-methyl-l-propanethiol. 2-methyl-l-propanethiol, ]-butanethiol, 1-pentanethiol, allyl sulfide, propyl sulfide, and butyl sulfide... 

Bei der reduktiven Elektrolyse von l-Chlor-2-methyl-2-phenyl-propan in waBrigem DMF (Leitsalz Tetrabutylammoniumtosylat) an Quecksilber (—2,4 V Platin-Anode) wird neben tert.-Butyl-benzol (—70% d.Th.) auch Isobutyl-benzol erhalten4. 

GTP was employed for the synthesis of block copolymers with the first block PDMAEMA and the second PDEAEMA, poly[2-(diisopropylamino)e-thyl methacrylate], PDIPAEMA or poly[2-(N-morpholino)ethyl methacrylate], PM EM A (Scheme 33) [87]. The reactions took place under an inert atmosphere in THF at room temperature with l-methoxy-l-trimethylsiloxy-2-methyl-1-propane, MTS, as the initiator and tetra-n-butyl ammonium bibenzoate, TBABB, as the catalyst. Little or no homopolymer contamination was evidenced by SEC analysis. Copolymers in high yields with controlled molecular weights and narrow molecular weight distributions were obtained in all cases. The micellar properties of these materials were studied in aqueous solutions. 

In a closely related approach, Yen and Chu have reported the preparation of tetra-hydro-/3-carbolinediketopiperazines employing a three-step Pictet-Spengler, Schot-ten-Baumann, and intramolecular ester amidation sequence (Scheme 6.233) [415]. Throughout the synthesis, the ionic liquid l-butyl-2,3-dimethylimidazolium hexa-fluorophosphate (bdmimPF6) was employed. In a typical experiment, (S)-tryptophan methyl ester was dissolved in a 1 1 mixture of the ionic liquid and tetrahydrofuran... 

To introduce the Rh-centre in the supported ionic liquid, a solution of [Rh(CO)2(acac)] in acetonitrile was treated with either the ligand tri(m-sulfonyl)triphenyl phosphine trisodium salt (TPPTS) or the ligand tri(m-sulfonyl)triphenyl phosphine tris(l- butyl-3-methyl-imidazolium) salt (TPPTI) (Rh/P ratio of 1 10). The ligand TPPTI was found to dissolve in [BMIM][BF4] and... 

Fig. 3.174. Example of NACE electropherogram of mixture of dyes (1, Janus Green 2, Brilliant Cresyl Blue 3, Sudan Black 4, Thymolphtalein 5, Phenolphtalein) in acetonitrile. Added ionic liquid was l-butyl-3-methyl fluoroacetate (3.3 mg/ml). Applied voltage +18kV, current 8 pA. Reprinted with permission from M. Vaher et al. [207].

An ionic liquid was fully immobilized, rather than merely supported, on the surface of silica through a multiple-step synthesis as shown in Fig. 15 (97). A ligand tri(m-sulfonyl)triphenyl phosphine tris(l-butyl-3-methyl-imidazolium) salt (tppti) was prepared so that the catalyst, formed from dicarbonylacetylacetonate rhodium and the ligand (P/Rh = 10), could be soluble in both [BMIMJBFq and [BMIM]PF6. The supported ionic liquid-catalyst systems showed nearly three times higher rate of reaction (rate constant = 65 min ) that a biphasic system for the hydroformylation of 1-hexene at 100°C and 1500 psi in a batch reactor, but the n/i selectivity was nearly constant the same for the two ( 2.4). Unfortunately, both the supported and the biphasic ionic liquid systems exhibited similar metal leaching behavior. 

NONM Benzene, l-bromo-4 butyl-2-methyl-3, 5-dinitro... 

Some improvements occurred by changing to nitroxides with a hydrogen on at least one of the a-carbons of the piperidine ring, in contrast to TEMPO, which has no hydrogens on a-carbons. However, the major breakthrough came by using sterically hindered alicyclic nitroxides with a hydrogen on one of the a-carbons. f-Butyl 2-methyl-1-phenylpropyl nitroxide (LVIII) and f-butyl l-diethylphosphono-2,2-dimethylpropyl nitroxide (LIX) are examples of... 

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