L-Benzyl-2-methyl

Der Austausch des Sauerstoff-Atoms in 1-substituierten Imidazol-3-oxiden durch Nukleophile verlauft unter Angriff des Nukleophils in 2-Position. So erhalt man z. B. aus 1-Benzyl-4,5-dimethyl-imidazol-3-oxid mit Kaliumcyanid/Dimethylsulfat I-Benzyl-2-cyan-4,5-dime thy l-imidazol (65%), mit Phosphoroxychlorid l-Benzyl-2-chlor-4,5-dimethyl-imidazol (72%) bzw. mit Butindisaure-dimethylester l-Benzyl-2- (1,2-dimethoxycarbonyl-2-oxo-ethyl)-4,5-dimethyl-imidazol (83%)962. Analog wird l-Benzyl-5-methyl-imidazol-3-oxid mit z.B. Kaliumcyanid/Dimethylsulfat zu l-Benzyl-2-cyan-5-methyl-imidazol (75%) umgesetzt962. [Pg.167]

Benzyl- 571, 582, 591 l-Benzyl-4-brom- 577 l-Benzyl-3,4-dibrom- 577 l-Benzyl-5-halogen-4-nitro- 702 l-Benzyl-3-methyl- 577, 651 l-Benzyl-5-methyl- 577 l-Benzyl-5-nitro- 591 l-Benzyl-3,4,5-tribrom- 577 4,5-Dimethyl-l-hydroxy-3-phenyl- 408... [Pg.1175]

Benzyl-5-methoxy-1,3-dihydro-2//-benzimidazole-2-thione, B-00188 l-Benzyl-5-methyl-2,3-dihydro-2//-benzimidazole-2-thione, B-00189... [Pg.1277]

Acetoxy-l-benzyl-5-(2-methyl-2-propenyl)-2-p>rrolidinone Typical Procedure121 ... [Pg.836]

Zur schonenden Debenzylierung cyclischer N-Benzyl-ammonium-Salze kann man diese auch mit Lithium-propanthiolat in Phosphorsaure-tris-[dimethylamid] (HMPT) bei 0° bis 20° umsetzen. So erhalt man z. B. aus l-Benzyl-5-ethyl-l-methyl-l,2,3,6-tetrahydro-pyri-dinium-bromid 5-Ethyl-1-methyl-1,2,3,6-tetrahydro-pyridin (70%) und aus N-Benzyl-ca-tharanthinium-bromid Catharanthin (90%) ... [Pg.1222]

Some of the l-aryl-5-hydroxy-A2-l,2,3-triazolines with two different substituent groups at C-4 exist in solution as a mixture of the diastereomers they are readily interconvertible via a ketotriazene (59-62).259 The compositions of the equilibrium mixtures for a number of 1-methyl- and l-benzyl-5-hydroxy-A2-l,2,3-triazolines in solution were determined by NMR spectroscopy. The 8 values of the methyl groups at C-4 fall into two regions, namely at 81.41-1.57 or 1.05-1.21. They can be oriented either cis or trans relative to the hydroxy group at C-5. The compounds with bulky substituents at C-5 exist only in one form in which the bulky C-5 group is trans to the methyl group at C-4. The... [Pg.296]

Benzyl-l,6-naphthyridin-6-ium bromide (33) with methylmagnesium bromide gave crude 6-benzyl-5-methyl-5,6-dihydro-1,6-naphthyridine (34) (MeMgBr, THF, 5°C, substrate], slowly, 5°C, 10 min ), characterized by borohydride reduction to 6-benzyl-5-methyl-5,6,7,8-tetrahydro-l,6-naphthyridine (substrate, MeOH, pH7 buffer, 5°C NaBH4[ slowly, 5°C, 10 min 92% overall).1058... [Pg.99]

Benzyl mercaptan a-Toluenethiol (8) Benzenemethanethlol (9) (100-53-8) cis- and trans-5-Methyl-2-[l-raethyl-l-(phenylmethylth1o)ethyl]cyclohexanone Cyclohexanone, 5-methyl-2-[l-methyl-l-[(phenylmethyl]thio]ethyl]-, (2R-trans)-(10) (79563-58-9) (2S-c1s)- (10) (79618-04-5) 2-(l-Mercapto-l-methylethyl)-5-raethylcyclohexanol Cyclohexanol-2-(1-mercapto-l-methylethyl)-5-methyl-, [iR-(ia, 2a, 5a)]- (10) ... [Pg.267]

I -Benzyl-3,6-dichloro-2( l//)-pyrazinonc (127, R = Cl) gave l-benzyl-5-chloro-3-methyl-2(17/)-pyrazinone (127, R = Me) [Me4Sn, Pd(PPh3)4, PhMe, reflux, <5 days residue from evaporation, KF, AcOEt, 20°C, 12 h 81%) or its 3-ethyl ho-mologues (127, R = Et) (Et4Sn, likewise 95%) 391 analogues similarly.391... [Pg.98]

Methyl-2(lH)-pyrazinone (57) underwent quatemization to l-benzyl-3-methyl-5-oxo-4,5-dihydropyrazinium bromide (58) (PhCH2Br, EtOH, reflux, N2, 24 h 80%) that then gave the zwitterionic base, l-benzyl-5-methylpyrazin-l-ium-3-olate (59) [H20—MeOH, (Amberlite IRA-400, HO ) column 97% this indirect route offers a procedure for N-alkylation on a ring-N that is not adjacent to the oxo substituent] 341 l,5-dimethylpyrazin-l-ium-3-olate was made somewhat similarly.1478... [Pg.199]

Ethyl l-benzyl-5-ethoxy-2-piperazinecarboxylate (179) gave ethyl 7-benzyl-3-methyl-5,6,7,8-tetrahydroimidazo [1,2-a] pyrazine-6-carboxylate (181) (II2NCII2C=CII, PhMe, 100°C, 7 h %), presumably via the primary aminolytic product (180) analogues likewise.1468 Also other examples.129... [Pg.220]

In addition, l-benzyl-4-methyl-2-piperazinol (213) reacted with trimethylsilyl cyanide and boron trifluoride etherate to give l-benzyl-4-methyl-2-piperazinecar-bonitrile (214) (72% after separation from an isomer), which underwent partial dehydrogenation by m-chloroperoxybenzoic acid to afford 1 -benzyl-4-methyl-1,4,5,6-tetrahydro-2-pyrazinecarbonitrile (214a) in 53% yield 822 also, the oxime, 3-amino-6-hydroxyiminomethyl-2-pyrazinecarbonitrile 4-oxide (215) underwent... [Pg.330]

Benzyl-5-methyl-2-pyrazinamine 1-oxide 1 -Benzyl-5-methylpyrazin- l-ium-3-olate... [Pg.372]

Ethyl 3-amino- l-benzyl-5-isobutyl-6-oxo-1,6-dihydro-2-pyrazinecarboxylate 4-oxide Ethyl 3-amino-6-benzyloxy-5-isobutyl-2-pyrazinecarboxylate 4-oxide Ethyl 3-amino-6-chloro-5-ethoxy-2-pyrazinecarboxylate Ethyl 6-amino-3-chloromethyl-5-cyano-2-pyrazinecarboxylate Ethyl 6-amino-3-chloromethyl-5-cyano-2-pyrazinecarboxylate 1-oxide Ethyl 3-amino-5-chloro-6-methyl-2-pyrazinecarboxylate Ethyl 3-amino-5-chloro-6-phenyl-2-pyrazinecarboxylate Ethyl 5-amino-6-cyano-3-methyl-2-pyrazinecarboxylate Ethyl 6-amino-5-cyano-3-methyl-2-pyrazinecarboxylate Ethyl 6-amino-5-cyano-3-methyl-2-pyrazinecarboxylate 1-oxide Ethyl 3-amino-5,6-dimethyl-2-pyrazinecarboxylate 5-Ethylamino-6-ethylcarbamoyl-3-methylami no-2-pyrazinecarboxamide... [Pg.419]

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