L-aspartic acid peptides

Peptides and proteins having an aspartic acid residue undergo hydrolysis, isomerization, and racemization via cyclic imide formation. As shown in Scheme 80, L-aspartic acid peptide can isomerize to L-iso -aspartic acid peptide via its L-cyclic imide. The L-cyclic imide intermediate is capable of undergoing racemization to the D-cyclic imide and thus forms the D-aspartic acid peptide and the D-Ao-aspartic acid peptide on hydrolysis. 

Polymer additives can improve manufacturing processes and product quality, as they aid the formation of a continuous coating phase without any detrimental effect to the polymer. Biomedical applications of acrylic terpolymer with arginylglycylaspartic acid, i.e., a tripeptide composed of L-arginine, glycine and L-aspartic acid peptides, have been studied by Fussell and Cooper [39]. Chauhan and co-workers have investigated the biological activities of synthesised terpolymers based on p-hydroxybenzaldehyde... 

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