L-Allyl-2-

Conversion of 5-allylthioimidates into /V-allylthioamides is catalyzed by Pd(Il). 2-Allylthiopyridine (820) is converted into the less stable l-allyl-2-thio-pyridone 821 owing to Pd complex formation[509], Claisen rearrangement of 2-(allylthio)pyrimidin-4-(3//)-one (822) affords the A-l-allylation product 823 as the main product rather than the A -3-allylation product 824[510] The smooth rearrangement of the allylic thionobenzoate 825 to the allyl thiolo-benzoate 826 is catalyzed by both PdCl2(PhCN)2 and Pd(Ph3P)4 by different mechanisms[511],... 

Fused (5 5 5) heterocycle 28, along with 342, has been synthesized in 34% yield via an intramolecular nitrone cycloaddition, using l-allyl-2-pyrrole carboxaldehyde 340 as a starting material (Scheme 72) <1998JOC9279>. 

Allyl carbamide, al02 Allyl chloride, c236a Allyl cyanide, b482 Allyl glycidyl ether, a91 l-Allyl-2-hydroxybenzene, a94 Allyl iodide, i50... 

Mercapto-benzimidazol wird von Allyl-bromid in Gegenwart von Natriumhydrogencarbonat zunachst am S-Atom zu 2-Allylthio-benzimidazol (60%) alkyliert. Beim Erwarmen wandert der Allyl-Rest (Claisen-Umlagerung) vom S- zum N-Atom, und man erhiilt l-Allyl-2-mer-capto-benzimidazol (50% Schmp. 115—117°)372. 

Optisch-aktive Diazotate sowie Alkylierungsmittel reagieren unter Konfigurationserhalt1. Neben den Meerwein-Salzen konnen als Alkylierungsmittel auch Alkylhalogenide, be-sonders Alkyljodide verwendet werden. Mit Allyljodid oder -bromid wird l-Allyl-2-(l-methyl-heptyl)-diazen-l-oxid erhalten, das sich zu 2-(l-Methyl-heptyl)-l-( 1-propenyl)-diazen-l-oxid umlagern lafit4 ... 

Yttrium-catalyzed diene cyclization/hydrosilylation was applied to the synthesis of aliphatic nitrogen heterocycles such as the indolizidine alkaloid ( )-epilupinine. l-Allyl-2-vinylpiperidine 30 was synthesized in four steps in 59% overall yield from commercially available ( )-2-piperidinemethanol (Scheme 10). Treatment of 30 with phenylsilane and a catalytic amount of Gp 2YGH3(THF) gave silylated quinolizidine derivative 31 in 84% yield, resulting from selective hydrometallation of the A-allyl G=G bond in preference to the exocyclic vinylic G=G bond. Oxidation of the crude reaction mixture with tert-huVf hydrogen peroxide and potassium hydride gave (i)-epilupinine in 51-62% yield from 30 (Scheme 10). 

Yttrium-catalyzed cyclization/hydrosilylation was also applied to the synthesis of silylated heteroaromatic bicyclic compounds. Reaction of l-allyl-2-vinyl pyrrole (32, n = R = H) with phenylsilane catalyzed by [(Gp )2YMe]2 at room temperature for 6 h followed by oxidation gave the corresponding heterobicycle amine 33 in 90% yield as a 98 2 mixture of isomers (Equation (23)). It was noteworthy that selective conversion of 32 to 33 required initial... 

In a similar manner, the cyclohydrocarbonylation of A -l-allyl-2-formylpyrrole 80a-c afforded 7-formyl-5,6-dihydroin-dolizine 84a-c in good yield through one-pot cascade hydroformylation-aldol condensation process (Scheme 13)." ... 

Chervil Anthriscus cerefo-lium (L.) Hoffm. Estragol (75-80), l-allyl-2,4-di-methoxy benzene (16-22)... 

Naphthofurans have been synthesized from the corresponding naphthols thus 2-methoxy-3-allylnaphthalene (from allyl bromide and 3-lithio-2-methoxynaphthalene) gives 2-methyl-2,3-dihydronaphtho-[2,3-6]furans,435 and l-allyl-2-naphthol gives (with pyridine hydrochloride) 2-methyl-2,3-dihydronaphtho[2, l-6]furan.438... 

SYNTHESIS Apiole, as the crystalline essential oil l-allyl-2,5-dimethoxy-3,4-methylenedioxybenzene, is isolated directly from commercial Oil of Parsley, by... 

The tetramethoxy pattern. The third and last of the tetra-oxygenated essential oils, is l-allyl-2,3,4,5-tetraniethoxybenzene. This is present as a minor component in the oil of parsley, but it is much more easily obtained by synthesis. It, and its iso-compound, and the animation product, are discussed under the last of theTen Essential Amphetamines, TA. 

To a solution of 30 g impure 2-allyl-4,6-dimethoxyphcnol in a little absolute EtOH there was added a boiling solution of 8.7 g KOH in 75 mL absolute EtOH followed, immediately, by 22.4 g methyl iodide in a little EtOH. The mixture was held at reflux for 3 h, then added to 4 volumes of H20. Sufficient 10% NaOH was added to make the mixture strongly basic, and this was extracted with 4x100 mL Et20. Removal of the solvent gave 28 g of l-allyl-2,3,5-trimethoxybenzene. GC analysis showed some 10% of the expected impurity, 1,2,4-trimethoxybenzene. 

To a solution of 26 g cmde l-allyl-2,3,5-trimethoxybenzene in an equal weight of absolute EtOH there was added 52 g of flaked KOH. The mixture was... 

I love the British modesty that is shown by hiding a person s physical weight by referring to it with the dimension known as the stone. This is, as I remember, something like 14 pounds. So, if stones were the weight equivalent of 10 milligrams, the activity of TA would be several stone. And since the synthetic intermediate l-allyl-2,3,4,5-tetramethoxybenzene is one of the ten essential oils, the amination step from our hypothetical reaction in the human liver would make TA one of the so-called Ten Essential Amphetamines. 

Bromocyclocarbamation reaction of l-allyl-2-[( R)-menthyloxycarbo-nyl] derivatives of Reisert compounds 102 was accompanied by BrOMe addition to the C(3)-C(4) double bond to give 2-bromo-methyl-[l,3]oxazino[4,3-a]isoquinoline-4-ones 103 either under condition A with Br2 or under condition B using pyridinium tribromides (08JHC1651). 

A-l-Allyl-2-formylpyrrole, cyclohydrocarbonylation, 11, 521 Allyl glycosides, isomerization, 10, 91 Allyl halides, in copper-mediated substitutions, 9, 549-550 Allylic alcohols... 

Methoxy-4,5-azimidobenzoic acid l-Allyl-2-aminomethyl pyrrolidine Phosphoric anhydride... 

Chemical Name N-(l -Allyl-2,-pyrrolidylmethyl)-2,3-dimethoxy-5-sulfamoylbenzamide... 

Dimethoxy-5-sulfamoylbenzoic acid Carbonyldiimidazole l-Allyl-2-aminomethyl pyrrolidine... 

The mixture is agitated for 30 minutes at normal temperature, then 6.7 g (0.948 mol) of l-allyl-2-aminomethylpyrrolidine is added. The mixture is left under agitation for 5 hours at 20°C, then the solvent is evaporated under vacuum and the residue treated with 150 ml of water. The crystals are washed and dried. 

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